Journal
POWDER TECHNOLOGY
Volume 404, Issue -, Pages -Publisher
ELSEVIER
DOI: 10.1016/j.powtec.2022.117442
Keywords
Nano-silica; Herbal powder; Direct compaction; Bell-shaped effect; Co-processing
Categories
Funding
- National Natural Science Foundation of China, China [81973490]
- Natural Science Foundation of Shanghai, China [20ZR1458400]
- Clinical Research Fund of Shanghai Municipal Health Commission, China [202140347]
- Science and Technology Planning Project of Ningbo (Public welfare projects), China [202002N3146]
- Graduate Student Innovation Ability Project of Shanghai University of Traditional Chinese Medicine, China [Y2021086]
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This study aims to improve the direct compaction properties of Citri Reticulatae Pericarpium powder by liquid dispersion co-processing with hydrophilic or hydrophobic nano-silica. The results showed that hydrophilic nano-silica significantly improved the tabletability of Citri Reticulatae Pericarpium powder, while hydrophobic nano-silica improved the flowability. The different distribution patterns and surface properties of the nano-silica were the key reasons for their different effects on the powder.
This work aims to improve direct compaction properties of Citri Reticulatae Pericarpium powder (CB) by liquid dispersion co-processing with hydrophilic or hydrophobic nano-silica (INS or ONS). Such wet co-processing was applied to evenly distribute NS to CB. Typically, INS achieved up to 13.8-fold improvement in CB tabletability by affecting both bonding area and bonding strength. In comparison, ONS did better in improving flowability (angle of repose from 35.6 degrees to 27.8 degrees) and achieved up to 4.2-fold improvement in tabletability. Moreover, the bulk density of CB-NS was increased to ~0.65 g/mL at the ratio of 10:1. There was generally a bell-shaped relationship between improvements and CB/NS ratios, especially for ONS. The different distribution pattern and surface nature of INS and ONS caused by polarity difference were the key reasons for their different effects. Compared to the traditional MCC-based formulation strategy, qualified tablets with 3-fold higher CB loading (91.0%) were achieved. (c) 2022 Published by Elsevier B.V.
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