4.6 Article

Lack of impact of OCTN1 gene polymorphisms on clinical outcomes of gabapentinoids in Pakistani patients with neuropathic pain

Related references

Note: Only part of the references are listed.
Article Pharmacology & Pharmacy

Influence of single nucleotide polymorphism of LAT1 on therapeutic response to gabapentinoids in Pakistani patients with neuropathic pain

Abida Shaheen et al.

Summary: The study revealed that LAT1 rs4240803 genetic polymorphism affects the clinical efficacy and tolerability of gabapentinoids in patients. GA genotype was more common in the non-responder group, while patients with GG genotype showed better response to treatment.

BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY (2021)

Article Multidisciplinary Sciences

Effects of dose titration on adherence and treatment duration of pregabalin among patients with neuropathic pain: A MarketScan database study

Yu-Chen Yeh et al.

Summary: The study found that dose titration of pregabalin can improve treatment adherence and persistence in patients with neuropathic pain, providing valuable evidence to increase physician awareness of dose recommendations and educate patients on the importance of titration and adherence.

PLOS ONE (2021)

Article Pharmacology & Pharmacy

Population pharmacokinetics of gabapentin in patients with neuropathic pain: Lack of effect of diabetes or glycaemic control

Ana Carolina Conchon Costa et al.

Summary: This study evaluated the impact of diabetes and glycemic control on the population pharmacokinetics of Gabapentin (GBP). The research found that in patients with neuropathic pain, the pharmacokinetic model accurately estimated GBP concentrations using estimated glomerular filtration rate as a covariate for total clearance. The distribution and elimination processes of GBP were not affected by hyperglycemia or diabetes.

BRITISH JOURNAL OF CLINICAL PHARMACOLOGY (2021)

Article Pharmacology & Pharmacy

Pharmacogenetics-based population pharmacokinetic analysis of gabapentin in patients with chronic pain: Effect of OCT2 and OCTN1 gene polymorphisms

Priscila A. Yamamoto et al.

BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY (2019)

Article Biochemistry & Molecular Biology

Identification of drug transporters contributing to oxaliplatin-induced peripheral neuropathy

Shunsuke Fujita et al.

JOURNAL OF NEUROCHEMISTRY (2019)

Article Endocrinology & Metabolism

PREGABALIN TREATMENT OF PERIPHERAL NERVE DAMAGE IN A MURINE DIABETIC PERIPHERAL NEUROPATHY MODEL

J. Li et al.

ACTA ENDOCRINOLOGICA-BUCHAREST (2018)

Review Biochemistry & Molecular Biology

The Importance of Patient-Specific Factors for Hepatic Drug Response and Toxicity

Volker M. Lauschke et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2016)

Article Pharmacology & Pharmacy

L503F variant of carnitine/organic cation transporter 1 efficiently transports metformin and other biguanides

Azusa Futatsugi et al.

JOURNAL OF PHARMACY AND PHARMACOLOGY (2016)

Article Pharmacology & Pharmacy

Dosing Time-Dependent Changes in the Analgesic Effect of Pregabalin on Diabetic Neuropathy in Mice

Takahiro Akamine et al.

JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2015)

Article Pharmacology & Pharmacy

Transport of gabapentin by LAT1 (SLC7A5)

David Dickens et al.

BIOCHEMICAL PHARMACOLOGY (2013)

Article Chemistry, Medicinal

Involvement of Carnitine/Organic Cation Transporter OCTN1/SLC22A4 in Gastrointestinal Absorption of Metformin

Noritaka Nakamichi et al.

JOURNAL OF PHARMACEUTICAL SCIENCES (2013)

Review Pharmacology & Pharmacy

A Comparison of the Pharmacokinetics and Pharmacodynamics of Pregabalin and Gabapentin

Howard N. Bockbrader et al.

CLINICAL PHARMACOKINETICS (2010)

Article Pharmacology & Pharmacy

The Effects of Genetic Polymorphisms in the Organic Cation Transporters OCT1, OCT2, and OCT3 on the Renal Clearance of Metformin

M. V. Tzvetkov et al.

CLINICAL PHARMACOLOGY & THERAPEUTICS (2009)

Article Pharmacology & Pharmacy

Effects of genetic variation in the novel organic cation transporter, OCTN1, on the renal clearance of gabapentin

T. J. Urban et al.

CLINICAL PHARMACOLOGY & THERAPEUTICS (2008)

Review Biochemistry & Molecular Biology

Genetic polymorphisms of drug transporters: pharmacokinetic and pharmacodynamic consequences in pharmacotherapy

Ichiro Ieiri et al.

EXPERT OPINION ON DRUG METABOLISM & TOXICOLOGY (2006)

Article Gastroenterology & Hepatology

Evidence for association of OCTN genes and IBD5 with ulcerative colitis

S. Waller et al.

Article Medicine, Research & Experimental

Involvement of OCTN1 (SLC22A4) in pH-dependent transport of organic cations

Ikumi Tamai et al.

MOLECULAR PHARMACEUTICS (2004)

Article Genetics & Heredity

Functional variants of OCTN cation transporter genes are associated with Crohn disease

VD Peltekova et al.

NATURE GENETICS (2004)

Article Pharmacology & Pharmacy

Pharmacokinetics of pregabalin in subjects with various degrees of renal function

EJ Randinitis et al.

JOURNAL OF CLINICAL PHARMACOLOGY (2003)