4.6 Article

Altered stability of nuclear lamin-B marks the onset of aging in male Drosophila

Related references

Note: Only part of the references are listed.
Article Biochemistry & Molecular Biology

Lamin B1 decline underlies age-related loss of adult hippocampal neurogenesis

Tracy A. Bedrosian et al.

Summary: The age-dependent decline of lamin B1 in adult neural stem/progenitor cells is associated with alterations in adult hippocampal neurogenesis and anxiety-like behavior in mice, indicating a role in stem cell aging and mood regulation.

EMBO JOURNAL (2021)

Article Biochemistry & Molecular Biology

Lamin B1 acetylation slows the G1 to S cell cycle transition through inhibition of DNA repair

Laura A. Murray-Nerger et al.

Summary: Acetylation of lamin B1 at K134 is a molecular switch that controls nuclear periphery stability, cell cycle progression, and DNA repair. This modification prevents lamin disruption during HSV-1 infection, delays DNA damage resolution, and sustains activation of the G1/S checkpoint. Acetylation of LMNB1 negatively regulates canonical nonhomologous end joining and impacts DNA repair pathway choice.

NUCLEIC ACIDS RESEARCH (2021)

Article Cell Biology

NELF-A controls Drosophila healthspan by regulating heat-shock protein-mediated cellular protection and heterochromatin maintenance

Zhen-Kai Ngian et al.

Summary: Neuronal dosage of NELF-A in Drosophila has a significant impact on various aspects of aging by regulating transcription of Hsp genes in the brain, which suggests a potential therapeutic strategy against age-related diseases like neurodegeneration. The effects of NELF-A depletion on enhancing resistance to oxidative stress and reconfiguring the epigenome are highly conserved and can also be observed in human cells.

AGING CELL (2021)

Review Cell Biology

Insight into the functional organization of nuclear lamins in health and disease

Meltem Tatli et al.

CURRENT OPINION IN CELL BIOLOGY (2018)

Letter Biochemistry & Molecular Biology

CDK5-mediated phosphorylation of CP190 may regulate locomotor activity in adult female Drosophila

Chin-Tong Ong et al.

JOURNAL OF GENETICS AND GENOMICS (2018)

Review Cell Biology

Nuclear Lamins: Thin Filaments with Major Functions

Rebecca de Leeuw et al.

TRENDS IN CELL BIOLOGY (2018)

Article Biochemistry & Molecular Biology

Lamin Dysfunction Mediates Neurodegeneration in Tauopathies

Bess Frost et al.

CURRENT BIOLOGY (2016)

Article Biochemistry & Molecular Biology

AKT1-mediated Lamin A/C degradation is required for nuclear degradation and normal epidermal terminal differentiation

A. S. Naeem et al.

CELL DEATH AND DIFFERENTIATION (2015)

Review Cell Biology

Epigenetic regulation of ageing: linking environmental inputs to genomic stability

Berenice A. Benayoun et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2015)

Article Biochemistry & Molecular Biology

Age-Associated Loss of Lamin-B Leads to Systemic Inflammation and Gut Hyperplasia

Haiyang Chen et al.

Article Biochemical Research Methods

The cellular thermal shift assay for evaluating drug target interactions in cells

Rozbeh Jafari et al.

NATURE PROTOCOLS (2014)

Article Cell Biology

Lamin B1 loss is a senescence-associated biomarker

Adam Freund et al.

MOLECULAR BIOLOGY OF THE CELL (2012)

Article Cell Biology

The role of nuclear lamin B1 in cell proliferation and senescence

Takeshi Shimi et al.

GENES & DEVELOPMENT (2011)

Article Multidisciplinary Sciences

Characterization of lamin Mutation Phenotypes in Drosophila and Comparison to Human Laminopathies

Andres Munoz-Alarcon et al.

PLOS ONE (2007)