Journal
PLOS ONE
Volume 17, Issue 3, Pages -Publisher
PUBLIC LIBRARY SCIENCE
DOI: 10.1371/journal.pone.0266092
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Funding
- FAMYNorrbotten, FAMY-Vasterbotten och the AMYL foundation
- Erik, Karin and Gosta Selanders Foundation
- P.O. Zetterling Foundation
- Swedish Heart and Lung foundation [20160787]
- Swedish Research Council [2019-01338]
- Region of Vasterbotten
- Knut and Alice Wallenberg foundation
- Swedish Research Council [2019-01338] Funding Source: Swedish Research Council
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The study shows that the composition of amyloid fibrils in ATTRVal30Met amyloidosis patients does not change over time, even with a longer disease duration. This indicates that the composition of amyloid fibrils is not due to slow degradation over time.
Background We have previously shown that transthyretin (TTR) amyloidosis patients have amyloid fibrils of either of two compositions; type A fibrils consisting of large amounts of C-terminal TTR fragments in addition to full-length TTR, or type B fibrils consisting of only full-length TTR. Since type A fibrils are associated with an older age in ATTRVal30Met (p.Val50Met) amyloidosis patients, it has been discussed if the TTR fragments are derived from degradation of the amyloid deposits as the patients are aging. The present study aimed to investigate if the fibril composition type changes over time, especially if type B fibrils can shift to type A fibrils as the disease progresses. Material and methods Abdominal adipose tissue biopsies from 29 Swedish ATTRVal30Met amyloidosis patients were investigated. The fibril type in the patients initial biopsy taken for diagnostic purposes was compared to a biopsy taken several years later (ranging between 2 and 13 years). The fibril composition type was determined by western blot. Results All 29 patients had the same fibril composition type in both the initial and the follow-up biopsy (8 type A and 21 type B). Even patients with a disease duration of more than 12 years and an age over 75 years at the time of the follow-up biopsy had type B fibrils in both biopsies. Discussion The result clearly shows that the amyloid fibril composition containing large amounts of C-terminal fragments (fibril type A) is a consequence of other factors than a slow degradation process occurring over time.
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