Journal
PLASMA PROCESSES AND POLYMERS
Volume 19, Issue 9, Pages -Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/ppap.202200026
Keywords
cancer therapy; plasma activated liquid; radiation therapy; radioresistant tumor; synergy
Funding
- Ian and Margaret Bailey
- Research Training program Scholarship
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The study shows that plasma activated liquid can enhance the cytotoxicity of radiation on cancer cells while exhibiting an antagonistic effect on normal cells. These findings demonstrate the potential to improve cancer treatment efficacy and reduce toxicity.
Plasma activated liquid (PAL) is an emerging cancer treatment. Two prostate cell lines and one melanoma cell line were used in clonogenic assays to assess the cytotoxicity of PAL and radiation individually and in combination, using the multiplicative survival method to quantify interactions between the treatments. PAL applied before a dose of radiation synergistically increases cytotoxicity in cancer cells, while in immortalized normal cells, the combined treatment was found to be antagonistic. These results demonstrate the potential to improve the therapeutic window of cancer treatment, giving a higher cancer response rate with less toxicity.
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