Journal
PLANTA MEDICA
Volume 89, Issue 2, Pages 194-207Publisher
GEORG THIEME VERLAG KG
DOI: 10.1055/a-1829-9546
Keywords
Protopine; Eschscholzia californica; Papaveraceae; placental barrier; ex vivo cotyledon perfusion; pregnancy
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The placental passage of protopine was examined using a human ex vivo placental perfusion model. The study demonstrated that protopine can cross the placental barrier without affecting the viability and functionality of the placenta.
The placental passage of protopine was investigated with a human ex vivo placental perfusion model. The model was first validated with diazepam and citalopram, 2 compounds known to cross the placental barrier, and antipyrine as a positive control. All compounds were quantified by partially validated U(H)PLC-MS/MS bioanalytical methods. Protopine was transferred from the maternal to the fetal circuit, with a steady-state reached after 90 min. The study compound did not affect placental viability or functionality, as glucose consumption, lactate production, and beta-human chorionic gonadotropin, and leptin release remained constant. Histopathological evaluation of all placental specimens showed unremarkable, age-appropriate parenchymal maturation with no pathologic findings.
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