Journal
PLANT FOODS FOR HUMAN NUTRITION
Volume 77, Issue 2, Pages 292-298Publisher
SPRINGER
DOI: 10.1007/s11130-022-00968-1
Keywords
Chlorella pyrenoidosa; Anti-diabetic; Glucose metabolism; Gene expression; Gut microbiota
Funding
- Xiamen Marine Science and Technology Achievement Transformation and Industrialization Demonstration Project [18CYY026HJ13]
- Major Science and Technology Project of Fujian Province [2020NZ012010]
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CGSGCG exhibits anti-diabetic effects by reducing blood glucose, improving gut microbiota, and regulating relevant signaling pathways.
The aim of the present study was to investigate the anti-diabetic effect of CGSGCG and its beneficial effects on gut microbiota in type 2 diabetes (T2D) mice induced by streptozotocin and high sucrose and high fat diet. The results showed that treatment with CGSGCG reduced fasting blood glucose, improved oral glucose tolerance test, protected the liver from injury, and reduced inflammation in T2D mice. The contents of acetic acid, propionic acid, butyric acid, isobutyric acid, valeric acid and isovaleric acid in CGSGCG group were 2.49-, 1.74-, 3.31-, 1.93-, 1.36- and 1.30-fold than that of the model group. Moreover, administration of CGSGCG up-regulated the expression of INSR/IRS-1/PI3K/AKT/GLUT4 and mTOR but down-regulated the P38MAPK expression. Furthermore, the abundance of beneficial bacteria such as Verrucomicrobia, Proteobacteria, Osillibacter, Dubosiella and Lactococcus in intestinal tract increased, indicating that CGSCGG regulated and improved the bacterial community structure of T2D mice, which were closely related to glycometabolism.
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