Journal
PLANT BIOSYSTEMS
Volume 156, Issue 6, Pages 1314-1324Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/11263504.2022.2048274
Keywords
Helianthemum lippi; HPLC-UV-ESI-QTOF-MS analysis; cytotoxic effects; antimicrobial activity; antibiofilm activity
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Funding
- European Union from the Italian Ministry of Education, University and Research [ARS01_00432]
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This study determined the phytochemical composition of different extracts of Helianthemum lippii and evaluated their anticancer, antimicrobial, and antibiofilm activities. The extracts showed cytotoxic activity against human MDA-MB231 and HCT116 cells and antimicrobial activity against certain bacteria and fungi. These extracts demonstrate interesting therapeutic potential.
Helianthemum lippii is a perennial shrubby plant growing in the sandy environments of Italy, Mediterranean countries of North Africa and Middle East. H. lippii is used in traditional medicine but there are very few reports referring to the phytochemical characterization, the ethnopharmacology, and the biological activity of H. lippii. The goal of this study was to determine the phytochemical composition of different H. lippii extracts, cold (CME) and hot (HME) methanol, cold (CPEE) and hot (HPEE) petroleum ether, as well as to evaluate their anticancer and antimicrobial activities and biofilm formation reduction. Fifty-fours phytocompounds have been determined by HPLC-UV-ESI-QTOF-MS analysis. All the four extracts reduced the viability of human MDA-MB231 and HCT116 cells, being cold and hot methanol extracts the most effective. The antimicrobial activity against S. aureus, P. aeruginosa, E. faecalis, E. coli, C. albicans was also evaluated. Data showed the greater susceptibility of S. aureus to hot methanolic extract. Concerning antifungal activity, C. albicans resulted more susceptible to petroleum ether. Moreover, some of the samples exhibited a good antibiofilm activity both on immature and on mature biofilms. The four extracts showed interesting antimicrobial and cytotoxic activities and can be considered good candidates for new therapeutic applications
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