Journal
JOURNAL OF APPLIED PHYCOLOGY
Volume 29, Issue 1, Pages 531-542Publisher
SPRINGER
DOI: 10.1007/s10811-016-0942-0
Keywords
Fucoidan; Diabetic nephropathy; HSPG; Glycosaminoglycan; Inflammatory cytokines
Funding
- Natural Science Foundation of China [41376166]
- Qingdao National Laboratory for Marine Science and Technology [2015ASKJ02]
- Science and Technology Development Project of Shandong Province [2014GHY115017]
- Special Fund for Marine Scientific Research in the Public Interest [201405040]
- Special Found for Marine Scientific Research in Huangdao District [2014-04-11]
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Diabetic nephropathy (DN) is a type of serious microangiopathy that is caused by diabetes mellitus (DM). It is the most common cause of chronic renal failure and end-stage renal disease, and it severely affects patients' quality of life. This work aims to study the effect and mechanism of low molecular weight fucoidan (LMWF) on streptozotocin (STZ)-induced DN. The experimental results showed that LMWF prevented weight loss in DN rats, significantly reduced the levels of biochemical indexes in blood and urine samples, and also lowered hyaluronic acid (HA) levels and advanced glycosylation end product-specific receptor (AGER) levels in DN rats. LMWF maintained the structural integrity of glomerular basement membrane (GBM) and glomerulus, improved the glomerular filtration function, protected glycosaminoglycan from abnormal degrading, prevented advanced glycosylation end product (AGE) from being generated and accumulating, and also alleviated inflammatory response in DN rats. LMWF could obviously ameliorate and slow the development and progression of DN in rats.
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