4.7 Review

The naturally-derived alkaloids as a potential treatment for COVID-19: A scoping review

Related references

Note: Only part of the references are listed.
Article Biochemistry & Molecular Biology

Withanone and Withaferin-A are predicted to interact with transmembrane protease serine 2 (TMPRSS2) and block entry of SARS-CoV-2 into cells

Vipul Kumar et al.

Summary: A study examined the binding potential of natural compounds Withaferin-A, Withanone, and caffeic acid phenethyl ester to the cell surface receptor TMPRSS2 using molecular docking and molecular dynamics simulations. The results showed that Withanone had stronger interactions with TMPRSS2 and was able to induce changes in its allosteric site. Furthermore, Withanone downregulated TMPRSS2 mRNA expression, suggesting its potential dual action in blocking SARS-CoV-2 entry into host cells.

JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS (2022)

Article Biochemistry & Molecular Biology

Caffeine and caffeine-containing pharmaceuticals as promising inhibitors for 3-chymotrypsin-like protease of SARS-CoV-2

Amin O. Elzupir

Summary: This study investigates the inhibitory effect of caffeine and caffeine-containing pharmaceuticals on SARS-CoV-2 3-chymotrypsin-like protease (3CL(pro)). The study finds that seven FDA-approved drugs show good binding affinity to the catalytic residues of 3CL(pro). This in silico study demonstrates the potential of inexpensive drugs as inhibitors against 3CL(pro).

JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS (2022)

Article Chemistry, Multidisciplinary

A multi-targeting drug design strategy for identifying potent anti-SARS-CoV-2 inhibitors

Peng-xuan Ren et al.

Summary: This study implemented a multi-targeted anti-viral drug design strategy to discover highly potent SARS-CoV-2 inhibitors, which show effectiveness in impairing viral translation, frameshifting, replication, and assembly. This strategy led to the discovery of three alkaloids that inhibit SARS-CoV-2 with low nanomolar EC50 values, demonstrating the feasibility of multi-targeting drug design and providing a rationale for designing more potent anti-virus drugs.

ACTA PHARMACOLOGICA SINICA (2022)

Article Biochemistry & Molecular Biology

Potential inhibitors of coronavirus 3-chymotrypsin-like protease (3CLpro): an in silico screening of alkaloids and terpenoids from African medicinal plants

Gideon A. Gyebi et al.

Summary: The study screened alkaloids and terpenoids from African plants as potential inhibitors of coronavirus 3CL(pro). Over half of the top twenty compounds showed favorable interactions with coronaviruses 3CL(pro) and higher binding affinities than lopinavir and ritonavir. Seven promising compounds were identified, including four non-toxic, druggable plant-derived alkaloids and terpenoids that bind to the receptor-binding site and catalytic dyad of SARS-CoV-2 3CL(pro). Further experimental analyses are needed for developing these compounds as natural anti-COVID-19 therapeutic agents.

JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS (2021)

Article Biochemistry & Molecular Biology

Targeting SARS-CoV-2: a systematic drug repurposing approach to identify promising inhibitors against 3C-like proteinase and 2′-O-ribose methyltransferase

Rameez Jabeer Khan et al.

Summary: The study focused on identifying promising inhibitors from pre-existing antiviral drugs targeting two druggable proteins, 3CLpro and 2'-O-MTase, through screening and MD simulations to suggest potential therapeutic drugs against SARS-CoV-2.

JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS (2021)

Article Biochemistry & Molecular Biology

Understanding the binding affinity of noscapines with protease of SARS-CoV-2 for COVID-19 using MD simulations at different temperatures

Durgesh Kumar et al.

Summary: The current outbreak of novel coronavirus causing COVID-19 requires urgent identification of therapeutic agents, as there are currently no available antiviral drugs/vaccines. This study utilized computer-aided drug design to screen for potential inhibitors, identifying noscapine as a promising antiviral agent against coronavirus (SARS-CoV-2).

JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS (2021)

Article Biochemistry & Molecular Biology

Virtual screening-driven drug discovery of SARS-CoV2 enzyme inhibitors targeting viral attachment, replication, post-translational modification and host immunity evasion infection mechanisms

Mark Tristan J. Quimque et al.

Summary: Through bioinformatics and computational modeling, ninety seven antiviral secondary metabolites from fungi were found to have high binding affinities on five SARS-CoV2 enzymes. Among them, Quinadoline B (19) showed favorable ADMET values and high gastrointestinal absorptive probability but poor blood-brain barrier crossing capacities.

JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS (2021)

Article Biochemistry & Molecular Biology

Repurposing of FDA-approved antivirals, antibiotics, anthelmintics, antioxidants, and cell protectives against SARS-CoV-2 papain-like protease

Mahmoud Kandeel et al.

Summary: This study investigated the binding of SARS-CoV-2 PLpro with various drugs, identifying several potential candidates for treating COVID-19. Through simulations and calculations, the study analyzed the binding energies of these drugs, providing a primer for clinical application and guidance for further antiviral studies.

JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS (2021)

Article Biochemistry & Molecular Biology

In silico identification of widely used and well-tolerated drugs as potential SARS-CoV-2 3C-like protease and viral RNA-dependent RNA polymerase inhibitors for direct use in clinical trials

Seref Gul et al.

Summary: Despite the lack of clinically proven drugs for COVID-19, computationally screening clinically approved drugs has identified potential candidates for antiviral treatment.

JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS (2021)

Review Cardiac & Cardiovascular Systems

Efficacy and Safety of Colchicine in Post-acute Myocardial Infarction Patients: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

Carlos Diaz-Arocutipa et al.

Summary: The study evaluated the efficacy and safety of colchicine in post-acute myocardial infarction (MI) patients. Results showed that colchicine did not significantly reduce cardiovascular mortality, recurrent MI, or other cardiovascular outcomes, nor did it increase drug-related adverse events. The findings suggest that colchicine may not have a significant impact on post-acute MI patients in terms of reducing mortality or cardiovascular events.

FRONTIERS IN CARDIOVASCULAR MEDICINE (2021)

Review Gastroenterology & Hepatology

COVID-19: Discovery, diagnostics and drug development

Tarik Asselah et al.

Summary: COVID-19 started in Wuhan in 2019 and has become a global pandemic. The virus responsible, SARS-CoV-2, shares a high sequence identity with bat- and pangolin-derived coronaviruses. Risk factors for SARS-CoV-2 infection include age, obesity, diabetes, and hypertension.

JOURNAL OF HEPATOLOGY (2021)

Article Chemistry, Physical

Identification of alkaloids from Justicia adhatoda as potent SARS CoV-2 main protease inhibitors: An in silico perspective

Rajesh Ghosh et al.

Summary: Using computational methods, this study found that an alkaloid (anisotine) from Justicia adhatoda leaf extracts exhibited good binding affinity to SARS CoV-2 Mpro, potentially making it a more potent inhibitor compared to the recommended antiviral drugs (lopinavir and darunavir). Further animal and patient experiments may validate anisotine as a promising anti-COVID-19 drug.

JOURNAL OF MOLECULAR STRUCTURE (2021)

Review Chemistry, Medicinal

Natural products forCOVID-19 prevention and treatment regarding to previous coronavirus infections and novel studies

Motahareh Boozari et al.

Summary: This review discusses the potential role of natural products in the treatment of COVID-19, suggesting promising herbal treatment options and highlighting the antiviral and immune-boosting effects of natural products against coronaviruses.

PHYTOTHERAPY RESEARCH (2021)

Article Pharmacology & Pharmacy

Unravelling high-affinity binding compounds towards transmembrane protease serine 2 enzyme in treating SARS-CoV-2 infection using molecular modelling and docking studies

M. Pooja et al.

Summary: The COVID-19 pandemic has prompted the search for effective drug candidates due to the lack of vaccines and drugs. This study focused on the TMPRSS2 enzyme as a potential pharmacological target and identified eight high affinity drug candidates through modeling and molecular docking studies.

EUROPEAN JOURNAL OF PHARMACOLOGY (2021)

Review Infectious Diseases

Remdesivir in Coronavirus Disease 2019 (COVID-19) treatment: a review of evidence

Hui Xian Jaime Lin et al.

Summary: Remdesivir has shown potential as a therapeutic agent against COVID-19, with evidence demonstrating its ability to shorten time to recovery and hospital stay for patients. However, further large-scale clinical trials are needed to validate these findings.

INFECTION (2021)

Article Chemistry, Physical

In silico study of the interactions of Pilocarpus microphyllus imidazolic alkaloids with the main protease (Mpro) of SARS-CoV-2

Ezio R. A. de Sa et al.

Summary: The in silico study investigates the imidazolic alkaloids of the species Pilocarpus microphyllus as potential inhibitors of the M-pro protease of SARS-CoV-2. The results suggest that these alkaloids may be promising targets as inhibitors for the enzyme and warrant further in vitro and in vivo testing.

MOLECULAR SIMULATION (2021)

Article Plant Sciences

Lycorine, a non-nucleoside RNA dependent RNA polymerase inhibitor, as potential treatment for emerging coronavirus infections

Young-Hee Jin et al.

Summary: Lycorine has been shown to efficiently inhibit various coronavirus infections, especially MERS-CoV and SARS-CoV-2, by directly inhibiting viral RdRp activity. Its binding affinities with SARS-CoV-2 RdRp residues are higher than those of remdesivir, indicating its potential as a candidate for combating the COVID-19 pandemic.

PHYTOMEDICINE (2021)

Article Biology

The potential of Paritaprevir and Emetine as inhibitors of SARS-CoV-2 RdRp

Arun Bahadur Gurung et al.

Summary: This study screened a set of FDA-approved antiviral drugs and antiviral phytocompounds, identifying Paritaprevir, Rilpivirine, and Simeprevir as the top three potential inhibitors among the drugs, and Emetine, 7,4-di-O-galloyltricetifavan, and Oleanolic acid as the top three hits among the phytocompounds.

SAUDI JOURNAL OF BIOLOGICAL SCIENCES (2021)

Article Multidisciplinary Sciences

Enhanced production of camptothecin by immobilized callus of Ophiorrhiza mungos and a bioinformatic insight into its potential antiviral effect against SARS-CoV-2

Rajesh Mamkulathil Devasia et al.

Summary: This study successfully immobilized tissue culture grown callus of Ophiorrhiza mungos to produce a higher concentration of CPT, and bioinformatically analyzed the binding potential of CPT towards two important proteins of SARS-CoV-2. Docking analysis showed a potential interaction of CPT against the external spike glycoprotein of SARS-CoV-2.

JOURNAL OF KING SAUD UNIVERSITY SCIENCE (2021)

Article Pharmacology & Pharmacy

Emetine suppresses SARS-CoV-2 replication by inhibiting interaction of viral mRNA with eIF4E

Ram Kumar et al.

Summary: Emetine has been shown to have antiviral effects against SARS-CoV-2 and infectious bronchitis virus by interfering with viral RNA synthesis and disrupting its binding with cellular proteins. Further research on emetine as a potential treatment for COVID-19 is warranted.

ANTIVIRAL RESEARCH (2021)

Article Biology

Structural insights on the interaction potential of natural leads against major protein targets of SARS-CoV-2: Molecular modelling, docking and dynamic simulation studies

Sinosh Skariyachan et al.

Summary: This study utilized molecular modeling, docking, and dynamic simulation to predict the interaction potential of natural lead molecules with prospective protein targets of SARS-CoV-2. Four natural molecules with ideal drug-like properties were identified, with Hyoscyamine and Tamaridone showing strong binding to spike glycoprotein, and Rotiorinol-C and Scutifoliamide-A demonstrating good binding to replicase polyprotein-1ab main protease.

COMPUTERS IN BIOLOGY AND MEDICINE (2021)

Article Pharmacology & Pharmacy

Drug designing against NSP15 of SARS-COV2 via high throughput computational screening and structural dynamics approach

Abida Batool et al.

Summary: The study aims to propose promising drug candidates against a potential therapeutic target of SARS-CoV2 and identifies a small molecule compound with potential efficacy against COVID-19 through integrative computational analysis.

EUROPEAN JOURNAL OF PHARMACOLOGY (2021)

Article Public, Environmental & Occupational Health

The role of C-reactive protein as a prognostic marker in COVID-19

Dominic Stringer et al.

Summary: The study found that a threshold of CRP >= 40 mg/L on admission is a good indicator for predicting inpatient mortality in COVID-19 patients. This threshold can assist clinicians in early assessment of patient severity, treatment decisions, and further care planning.

INTERNATIONAL JOURNAL OF EPIDEMIOLOGY (2021)

Review Virology

In Vitro and In Vivo Models for Studying SARS-CoV-2, the Etiological Agent Responsible for COVID-19 Pandemic

Rafael B. Rosa et al.

Summary: This review summarizes the main models of SARS-CoV-2 infection developed so far, including in vitro and in vivo models, and discusses their advantages, drawbacks, and main uses.

VIRUSES-BASEL (2021)

Article Multidisciplinary Sciences

Structure of papain-like protease from SARS-CoV-2 and its complexes with non-covalent inhibitors

Jerzy Osipiuk et al.

Summary: The study focused on papain-like protease (PLpro) as a potential target for antivirals against SARS-CoV-2, identifying inhibitors and their interactions with the enzyme. The findings demonstrate the potential for developing high-affinity inhibitors through structure-based drug design efforts targeting PLpro.

NATURE COMMUNICATIONS (2021)

Article Multidisciplinary Sciences

A SARS-CoV-2 cytopathicity dataset generated by high-content screening of a large drug repurposing collection

Bernhard Ellinger et al.

Summary: The study applied high-content screening to a collection of 5632 compounds, identifying 258 hits with potential inhibitory effects on SARS-CoV-2 cytopathicity. Known inhibitors were validated for their ability to reduce the cytopathic effects of the virus, providing confidence in the assay's validity. The data from high-content screening are suitable for reanalysis across different drug classes and indications, offering additional insights into SARS-CoV-2 mechanisms and potential therapeutic strategies.

SCIENTIFIC DATA (2021)

Article Chemistry, Medicinal

Plant-derived chemicals as potential inhibitors of SARS-CoV-2 main protease (6LU7), a virtual screening study

Mohsen Sisakht et al.

Summary: A dataset of plant-based natural compounds was screened for antiviral activity against SARS-CoV-2 main protease, with several phytochemicals identified as potential inhibitors that could be used in the fight against COVID-19.

PHYTOTHERAPY RESEARCH (2021)

Article Multidisciplinary Sciences

Reduced mortality in COVID-19 patients treated with colchicine: Results from a retrospective, observational study

Lucio Manenti et al.

Summary: This study found that the use of colchicine in COVID-19 patients was associated with reduced mortality and accelerated recovery, which was further supported by changes in inflammatory markers.

PLOS ONE (2021)

Article Virology

Quinine Inhibits Infection of Human Cell Lines with SARS-CoV-2

Maximilian Grosse et al.

Summary: This study found that quinine exhibited more effective antiviral activity against SARS-CoV-2 with lower toxicity compared to CQN and H-CQN. It showed antiviral activity in different cell lines, indicating its potential as a treatment option for SARS-CoV-2.

VIRUSES-BASEL (2021)

Article Chemistry, Multidisciplinary

Quinoline and Quinazoline Alkaloids against COVID-19: An In Silico Multitarget Approach

Esraa M. O. A. Ismail et al.

Summary: Following the recent outbreak of COVID-19, natural quinoline and quinazoline alkaloids have shown potential as multitarget drugs against the virus.

JOURNAL OF CHEMISTRY (2021)

Article Biochemistry & Molecular Biology

Comprehensive Virtual Screening of the Antiviral Potentialities of Marine Polycyclic Guanidine Alkaloids against SARS-CoV-2 (COVID-19)

Amr El-Demerdash et al.

Summary: The study aimed to evaluate the binding affinity of fifteen guanidine alkaloids against five proteins of SARS-CoV-2, with two compounds showing significantly favorable binding interactions. These promising results open up possibilities for further investigations against SARS-CoV-2.

BIOMOLECULES (2021)

Article Pharmacology & Pharmacy

Virtual high throughput screening: Potential inhibitors for SARS-CoV-2

Dhananjay Jade et al.

Summary: This study identified several compounds that inhibit SARS-CoV-2 proteases PLPRO and 3CLPRO through in silico virtual screening. These compounds demonstrated stability in molecular dynamics simulations and showed potential for treating COVID-19 infections.

EUROPEAN JOURNAL OF PHARMACOLOGY (2021)

Review Biochemistry & Molecular Biology

Possible Beneficial Actions of Caffeine in SARS-CoV-2

Bianca S. Romero-Martinez et al.

Summary: The COVID-19 pandemic has created a need for rapid development of effective treatments, with caffeine being suggested as potentially beneficial due to its anti-inflammatory, immunomodulatory, and bronchodilator effects. Further research is necessary to validate these potential benefits in vitro and in vivo models.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

Review Genetics & Heredity

The biological and clinical significance of emerging SARS-CoV-2 variants

Kaiming Tao et al.

Summary: The emergence of multiple SARS-CoV-2 variants has significant impacts on the epidemiological and clinical aspects of the COVID-19 pandemic, including increased virus transmission rates, heightened risk of reinfection, and reduced effectiveness of neutralizing antibodies and vaccines. These variants have introduced new challenges to COVID-19 research, necessitating additional avenues of laboratory, epidemiological, and clinical studies.

NATURE REVIEWS GENETICS (2021)

Article Pharmacology & Pharmacy

In silico Nigellidine (N. sativa) bind to viral spike/active-sites of ACE1/2, AT1/2 to prevent COVID-19 induced vaso-tumult/vascular-damage/comorbidity

Smarajit Maiti et al.

Summary: Nigellidine binds strongly to various angiotensin-binding proteins and the spike glycoprotein of COVID-19, potentially providing therapeutic benefits in COVID-19 patients by mitigating vascular disturbances caused by angiotensin dysregulations.

VASCULAR PHARMACOLOGY (2021)

Article Multidisciplinary Sciences

A high-throughput screen for TMPRSS2 expression identifies FDA-approved compounds that can limit SARS-CoV-2 entry

Yanwen Chen et al.

Summary: The research identified homoharringtonine and halofuginone as potential drugs to reduce TMPRSS2 expression, leading to decreased entry of SARS-CoV-2 into cells and increased resistance to infection.

NATURE COMMUNICATIONS (2021)

Article Critical Care Medicine

Colchicine for community-treated patients with COVID-19 (COLCORONA): a phase 3, randomised, double-blinded, adaptive, placebo-controlled, multicentre trial

Jean-Claude Tardif et al.

Summary: The study aimed to investigate the effect of colchicine on the composite of COVID-19-related death or hospital admission. Among patients with PCR-confirmed COVID-19, colchicine led to a lower rate of the composite of death or hospital admission than placebo.

LANCET RESPIRATORY MEDICINE (2021)

Article Biotechnology & Applied Microbiology

Anti-HIV reverse transcriptase plant polyphenolic natural products with in silico inhibitory properties on seven non-structural proteins vital in SARS-CoV-2 pathogenesis

Von Novi O. de Leon et al.

Summary: This study investigated the potential of anti-HIV reverse transcriptase phytochemicals as inhibitors of SARS-CoV-2 non-structural proteins, identifying polyphenolic functionalized natural products as effective multi-targeting agents. These compounds showed strong binding affinities to multiple nsps, good drug-like properties, gastrointestinal absorptive capabilities, and non-toxic characteristics, suggesting their potential as novel anti-COVID-19 drug prototypes.

JOURNAL OF GENETIC ENGINEERING AND BIOTECHNOLOGY (2021)

Article Chemistry, Physical

Antiviral drug design based on the opening mechanism of spike glycoprotein in SARS-CoV-2

Ruichao Mao et al.

Summary: In the study of novel coronavirus disease 2019, a promising treatment approach was identified by blocking the formation of key salt bridges that enable the virus to bind to host cells. Investigation into the role of a pair of salt bridges formed by K537 and E619 side chains revealed drug molecules that could be used for prevention and treatment.

PHYSICAL CHEMISTRY CHEMICAL PHYSICS (2021)

Article Nutrition & Dietetics

In Silico Study of the Active Compounds of Lindera aggregata (Sims) Kosterm as Anti-coronavirus

Elok R. Firdiana et al.

Summary: Secondary metabolites found in Lindera aggregata, such as terpenoids and alkaloids, demonstrate potential as anti-SARS-CoV-2 medication by inhibiting the virus's adsorption and replication; these compounds interacted with multiple target proteins in molecular docking analysis, showing strong binding affinity.

CURRENT NUTRITION & FOOD SCIENCE (2021)

Review Microbiology

Coronavirus biology and replication: implications for SARS-CoV-2

Philip V'kovski et al.

Summary: This review discusses key aspects of coronavirus biology and their implications for SARS-CoV-2 infections, treatment, and prevention strategies. Understanding virus-host interactions at the molecular level is crucial for developing effective intervention strategies. Summarizing the discoveries of SARS-CoV-2 infection and comparing it with other coronaviruses will support future preparedness and combat strategies.

NATURE REVIEWS MICROBIOLOGY (2021)

Article Rheumatology

Beneficial effects of colchicine for moderate to severe COVID-19: a randomised, double-blinded, placebo-controlled clinical trial

Maria Isabel Lopes et al.

Summary: Colchicine showed benefits in the treatment of COVID-19 patients by reducing the need for supplemental oxygen and length of hospitalisation. It did not necessarily reduce mortality, but was safe and well tolerated with the potential side effect of diarrhea.

RMD OPEN (2021)

Review Cardiac & Cardiovascular Systems

Special Article - The impact of 2019 novel coronavirus on heart injury: A Systematic review and Meta-analysis

Jing-Wei Li et al.

PROGRESS IN CARDIOVASCULAR DISEASES (2020)

Review Plant Sciences

Natural Products as Sources of New Drugs over the Nearly Four Decades from 01/1981 to 09/2019

David J. Newman et al.

JOURNAL OF NATURAL PRODUCTS (2020)

Article Medicine, Research & Experimental

SARS-CoV-2 RNA polymerase as target for antiviral therapy

Luigi Buonaguro et al.

JOURNAL OF TRANSLATIONAL MEDICINE (2020)

Article Pharmacology & Pharmacy

Remdesivir, lopinavir, emetine, and homoharringtonine inhibit SARS-CoV-2 replication in vitro

Ka-Tim Choy et al.

ANTIVIRAL RESEARCH (2020)

Article Public, Environmental & Occupational Health

In silico prediction of potential inhibitors for the Main protease of SARS-CoV-2 using molecular docking and dynamics simulation based drug-repurposing

Yogesh Kumar et al.

JOURNAL OF INFECTION AND PUBLIC HEALTH (2020)

Article Biochemical Research Methods

Molecular Binding Mechanism and Pharmacology Comparative Analysis of Noscapine for Repurposing against SARS-CoV-2 Protease

Neeraj Kumar et al.

JOURNAL OF PROTEOME RESEARCH (2020)

Article Pharmacology & Pharmacy

In vitro evaluation of antiviral activity of single and combined repurposable drugs against SARS-CoV-2

Andres Pizzorno et al.

ANTIVIRAL RESEARCH (2020)

Article Medicine, Research & Experimental

Analysis of SARS-CoV-2 RNA-dependent RNA polymerase as a potential therapeutic drug target using a computational approach

Syed Ovais Aftab et al.

JOURNAL OF TRANSLATIONAL MEDICINE (2020)

Article Medicine, Research & Experimental

Computational guided drug repurposing for targeting 2′-O-ribose methyltransferase of SARS-CoV-2

Kedar Sharma et al.

LIFE SCIENCES (2020)

Review Chemistry, Medicinal

Biologically active isoquinoline alkaloids covering 2014-2018

Xiao-Fei Shang et al.

MEDICINAL RESEARCH REVIEWS (2020)

Article Multidisciplinary Sciences

Chloroquine does not inhibit infection of human lung cells with SARS-CoV-2

Markus Hoffmann et al.

NATURE (2020)

Article Virology

Potential Antiviral Options against SARS-CoV-2 Infection

Aleksandr Ianevski et al.

VIRUSES-BASEL (2020)

Article Multidisciplinary Sciences

Molecular interaction and inhibition of SARS-CoV-2 binding to the ACE2 receptor

Jinsung Yang et al.

NATURE COMMUNICATIONS (2020)

Article Public, Environmental & Occupational Health

Antimalarial drugs inhibit the replication of SARS-CoV-2: An in vitro evaluation

Mathieu Gendrot et al.

TRAVEL MEDICINE AND INFECTIOUS DISEASE (2020)

Article Biotechnology & Applied Microbiology

Alkaloids from Cryptolepis sanguinolenta as Potential Inhibitors of SARS-CoV-2 Viral Proteins: An In Silico Study

Lawrence Sheringham Borquaye et al.

BIOMED RESEARCH INTERNATIONAL (2020)

Review Pharmacology & Pharmacy

Anti-SARS-CoV Natural Products With the Potential to Inhibit SARS-CoV-2 (COVID-19)

Surjeet Verma et al.

FRONTIERS IN PHARMACOLOGY (2020)

Article Medicine, General & Internal

Colchicine to Weather the Cytokine Storm in Hospitalized Patients with COVID-19

Luigi Brunetti et al.

JOURNAL OF CLINICAL MEDICINE (2020)

Article Biochemistry & Molecular Biology

In silico analysis of selected alkaloids against main protease (Mpro) of SARS-CoV-2

Saksham Garg et al.

CHEMICO-BIOLOGICAL INTERACTIONS (2020)

Article Biochemistry & Molecular Biology

Alkaloids: Therapeutic Potential against Human Coronaviruses

Burtram C. Fielding et al.

MOLECULES (2020)

Article Multidisciplinary Sciences

Enhancement of the IFN-β-induced host signature informs repurposed drugs for COVID-19

Chen-Tsung Huang et al.

HELIYON (2020)

Review Pharmacology & Pharmacy

Challenges for Drug Repurposing in the COVID-19 Pandemic Era

Janet Sultana et al.

FRONTIERS IN PHARMACOLOGY (2020)

Article Infectious Diseases

A Case Control Study to Evaluate the Impact of Colchicine on Patients Admitted to the Hospital with Moderate to Severe COVID-19 Infection

Tegveer Sandhu et al.

CANADIAN JOURNAL OF INFECTIOUS DISEASES & MEDICAL MICROBIOLOGY (2020)

Article Mathematics, Interdisciplinary Applications

Computational View toward the Inhibition of SARS-CoV-2 Spike Glycoprotein and the 3CL Protease

Zhen Qiao et al.

COMPUTATION (2020)

Review Chemistry, Medicinal

Berberine and barberry (Berberis vulgaris): A clinical review

Mohsen Imenshahidi et al.

PHYTOTHERAPY RESEARCH (2019)

Article Medicine, General & Internal

PRISMA Extension for Scoping Reviews (PRISMA-ScR): Checklist and Explanation

Andrea C. Tricco et al.

ANNALS OF INTERNAL MEDICINE (2018)

Article Multidisciplinary Sciences

Coronavirus nonstructural protein 15 mediates evasion of dsRNA sensors and limits apoptosis in macrophages

Xufang Deng et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2017)

Article Chemistry, Medicinal

The long story of camptothecin: From traditional medicine to drugs

Emanuela Martino et al.

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2017)

Article Biochemistry & Molecular Biology

Coronavirus Nsp10, a Critical Co-factor for Activation of Multiple Replicative Enzymes

Mickael Bouvet et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2014)