Journal
PHYTOTHERAPY RESEARCH
Volume 36, Issue 4, Pages 1616-1632Publisher
WILEY
DOI: 10.1002/ptr.7417
Keywords
curcumin; immunomodulatory effect; inflammation; systemic autoimmune diseases
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Systemic autoimmune diseases are characterized by immune system dysregulation, leading to immune cell activation, inflammation, and multi-organ impairment. Curcumin, a phenolic ingredient extracted from turmeric, has various functions such as inhibiting inflammation and oxidative stress. However, its immunomodulatory effects on immune reactions/processes are still largely unknown.
Systemic autoimmune diseases like rheumatoid arthritis, multiple sclerosis, and systemic lupus erythematosus represent various autoimmune conditions identified by immune system dysregulation. The activation of immune cells, auto-antigen outbreak, inflammation, and multi-organ impairment is observed in these disorders. The immune system is an essential complex network of cells and chemical mediators which defends the organism's integrity against foreign microorganisms, and its precise operation and stability are compulsory to avoid a wide range of medical complications. Curcumin is a phenolic ingredient extracted from turmeric and belongs to the Zingiberaceae, or ginger family. Curcumin has multiple functions, such as inhibiting inflammation, oxidative stress, tumor cell proliferation, cell death, and infection. Nevertheless, the immunomodulatory influence of curcumin on immunological reactions/processes remains mostly unknown. In the present narrative review, we sought to provide current information concerning the preclinical and clinical uses of curcumin in systemic autoimmune diseases.
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