Journal
PHYTOTHERAPY RESEARCH
Volume 36, Issue 5, Pages 2236-2245Publisher
WILEY
DOI: 10.1002/ptr.7441
Keywords
CVD; FMD; inflammation; Nigella sativa; vascular function
Categories
Funding
- AJA University of Medical Sciences
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This study found that N. sativa oil can improve vascular NO and FMD levels in participants with cardiovascular risk factors, but more research is needed to confirm its benefits on vascular inflammation.
Cardiovascular diseases (CVD) are the leading causes of mortality worldwide. Flow-mediated dilation (FMD) is a marker of vascular function. Beneficial cardiometabolic effects of Nigella sativa (N. sativa) have been observed. We evaluated the effect of N. sativa oil on FMD, plasma nitrite, and nitrate (NOx) as nitric oxide (NO) metabolites, and inflammatory markers in subjects with CVD risk factors. Fifty participants were randomly assigned to either the N. sativa (two capsules of 500 mg N. sativa oil) or the placebo group (two capsules of 500 mg mineral oil), for 2 months. The brachial FMD, plasma NOx, vascular cellular adhesion molecule-1 (VCAM-1), and intracellular adhesion molecule-1 (ICAM-1) were measured. FMD and plasma NOx levels was significantly increased in the N. sativa group compared to the placebo group (changes: 2.97 +/- 2.11% vs. 0.71 +/- 3.19%, p < 0.001 for FMD and 4.73 +/- 7.25 mu mol/L vs. 0.99 +/- 5.37 mu mol/L, p = 0.036 for plasma NOx). However, there was no significant difference in ICAM-1 and VCAM-1 levels between groups. Therefore, N. sativa oil improves vascular NO and FMD in subjects with cardiovascular risk factors. However, more studies are warranted to confirm the beneficial impacts of the N. sativa oil on vascular inflammation.
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