4.7 Article

6-methoxyflavone suppresses neuroinflammation in lipopolysaccharide-stimulated microglia through the inhibition of TLR4/MyD88/p38 MAPK/ NF-ΚB dependent pathways and the activation of HO-1/NQO-1 signaling

Related references

Note: Only part of the references are listed.
Article Chemistry, Medicinal

ω-3 DPA Protected Neurons from Neuroinflammation by Balancing Microglia M1/M2 Polarizations through Inhibiting NF-κB/MAPK p38 Signaling and Activating Neuron-BDNF-PI3K/AKT Pathways

Baiping Liu et al.

Summary: The study demonstrated that DPA can alleviate neuroinflammation and protect neurons from damage by affecting cytokine expression and pathway activation. This protective effect may be related to DPA balancing the polarization states of microglia.

MARINE DRUGS (2021)

Article Cell Biology

Saussureae Radix Attenuates Neuroinflammation in LPS-Stimulated Mouse BV2 Microglia via HO-1/Nrf-2 Induction and Inflammatory Pathway Inhibition

You-Chang Oh et al.

Summary: The activation of microglial cells and their neuroinflammatory reactions play a role in degenerative brain diseases, making regulation of their activation an important research focus for therapeutic agents. Saussureae Radix (SR) has shown potential in inhibiting neuroinflammation by reducing inflammatory mediators and promoting antioxidative pathways. Isolation and analysis identified key compounds in SR that could be beneficial in treating inflammation-related degenerative brain diseases.

MEDIATORS OF INFLAMMATION (2021)

Article Biochemistry & Molecular Biology

Ganoderic Acid A Attenuates LPS-Induced Neuroinflammation in BV2 Microglia by Activating Farnesoid X Receptor

Yue Jia et al.

Summary: Neuroinflammation plays a critical role in neurodegenerative diseases, and microglia-mediated neuroinflammation is the main cause. Ganoderic acid A (GAA) from Ganoderma lucidum showed anti-inflammatory effects. This study found that GAA can inhibit LPS-induced neuroinflammation in BV2 microglial cells by activating the FXR receptor.

NEUROCHEMICAL RESEARCH (2021)

Article Obstetrics & Gynecology

Melatonin Ameliorates LPS-Induced Testicular Nitro-oxidative Stress (iNOS/TNFα) and Inflammation (NF-kB/COX-2) via Modulation of SIRT-1

Jitendra Kumar et al.

Summary: This study demonstrated that melatonin protected testes from LPS-induced nitro-oxidative stress, inflammation, and associated damages by upregulating SIRT-1 expression.

REPRODUCTIVE SCIENCES (2021)

Article Biochemistry & Molecular Biology

Trem2 promotes anti-inflammatory responses in microglia and is suppressed under pro-inflammatory conditions

Wenfei Liu et al.

HUMAN MOLECULAR GENETICS (2020)

Article Neurosciences

Microglia and astrocyte dysfunction in parkinson's disease

Tae-In Kam et al.

NEUROBIOLOGY OF DISEASE (2020)

Article Integrative & Complementary Medicine

Phyllanthus amarus prevents LPS-mediated BV2 microglial activation via MyD88 and NF-kappa B signaling pathways

Elysha Nur Ismail et al.

BMC COMPLEMENTARY MEDICINE AND THERAPIES (2020)

Article Engineering, Biomedical

Microglia-targeting nanotherapeutics for neurodegenerative diseases

Nanxia Zhao et al.

APL BIOENGINEERING (2020)

Article Chemistry, Multidisciplinary

Pharmacological activation of REV-ERBα represses LPS-induced microglial activation through the NF-κB pathway

Dong-kai Guo et al.

ACTA PHARMACOLOGICA SINICA (2019)

Article Medicine, Research & Experimental

Icariside II attenuates lipopolysaccharide-induced neuroinflammation through inhibiting TLR4/MyD88/NF-κB pathway in rats

Jiayin Zhou et al.

BIOMEDICINE & PHARMACOTHERAPY (2019)

Article Neurosciences

Suicide and Microglia: Recent Findings and Future Perspectives Based on Human Studies

Hisaomi Suzuki et al.

FRONTIERS IN CELLULAR NEUROSCIENCE (2019)

Review Pharmacology & Pharmacy

Targeting Microglia and Macrophages: A Potential Treatment Strategy for Multiple Sclerosis

Jiaying Wang et al.

FRONTIERS IN PHARMACOLOGY (2019)

Review Pharmacology & Pharmacy

Targeting toll-like receptor 4 to modulate neuroinflammation in central nervous system disorders

Gunnar R. Leitner et al.

EXPERT OPINION ON THERAPEUTIC TARGETS (2019)

Article Radiology, Nuclear Medicine & Medical Imaging

Synthesis of 11C-labeled DNA polymerase-β inhibitor 5-methoxyflavone and PET/CT imaging thereof

Zude Chen et al.

NUCLEAR MEDICINE AND BIOLOGY (2019)

Review Neurosciences

Pharmacological Targeting of Microglial Activation: New Therapeutic Approach

Cai-Yun Liu et al.

FRONTIERS IN CELLULAR NEUROSCIENCE (2019)

Review Immunology

Immune cells and CNS physiology: Microglia and beyond

Geoffrey T. Norris et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2019)

Article Geriatrics & Gerontology

Hypertension Accelerates Alzheimer's Disease-Related Pathologies in Pigs and 3xTg Mice

Yao-Hsiang Shih et al.

FRONTIERS IN AGING NEUROSCIENCE (2018)

Review Neurosciences

Microglia in Neurological Diseases: A Road Map to Brain-Disease Dependent-Inflammatory Response

Sara Bachiller et al.

FRONTIERS IN CELLULAR NEUROSCIENCE (2018)

Article Medicine, Research & Experimental

The flavonoid 6-methoxyflavone allays cisplatin-induced neuropathic allodynia and hypoalgesia

Muhammad Shahid et al.

BIOMEDICINE & PHARMACOTHERAPY (2017)

Review Biochemistry & Molecular Biology

Nrf2 signaling pathway: Pivotal roles in inflammation

Syed Minhaj Uddin Ahmed et al.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE (2017)

Article Biochemistry & Molecular Biology

Modulation of Ionotropic GABA Receptors by 6-Methoxyflavanone and 6-Methoxyflavone

Belinda J. Hall et al.

NEUROCHEMICAL RESEARCH (2014)

Article Anatomy & Morphology

Differential distribution and activation of microglia in the brain of male C57BL/6J mice

Ting-Ting Yang et al.

BRAIN STRUCTURE & FUNCTION (2013)

Article Cell Biology

Methoxyflavones protect cells against endoplasmic reticulum stress and neurotoxin

Katsura Takano et al.

AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY (2007)