Journal
PHYTOMEDICINE
Volume 98, Issue -, Pages -Publisher
ELSEVIER GMBH
DOI: 10.1016/j.phymed.2022.153928
Keywords
Tangeretin; Osteoarthritis; Inflammation; NF-kappa B; Nrf2; MAPK
Categories
Funding
- Wenzhou Science and Technology Bureau Foundation [ZY2019014]
- National Natural Science Foundation of China [81871806]
- Lin He's New Medicine and Clinical Translation Academician Workstation Research Fund [18331213]
- Zhejiang Province Basic Public Welfare Research Program [LGF19H060008]
- Zhejiang Province Natural Science Foundation [LQ21H060010]
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Tangeretin, a natural flavonoid with anti-inflammatory properties, has been found to inhibit inflammation and extracellular matrix (ECM) degradation, effectively preventing the progression of osteoarthritis (OA). These effects are mediated through the Nrf2/NF-kappa B and MAPK/NF-kappa B pathways.
Background: Osteoarthritis (OA) is a globally prevalent degenerative disease characterized by extracellular matrix (ECM) degradation and inflammation. Tangeretin is a natural flavonoid that has anti-inflammatory properties. Studies have not explored whether tangeretin modulates OA development.& nbsp;Purpose: The aim of this study was to explore the potential effects and mechanism underlying the anti-OA properties of tangeretin.& nbsp;Study design: Effects of tangeretin on OA were detected in chondrocytes and OA mouse model.& nbsp;Methods: Protective effects of tangeretin on murine articular chondrocytes treated with interleukin-1 beta (IL-1 beta) were evaluated using qPCR, western blot analysis, ELISA, ROS detection and immunofluorescent staining in vitro. Healing effect of tangeretin on cartilage degradation in mice was assessed through X-ray imaging, histopathological analysis, immunohistochemical staining and immunofluorescent staining in vivo.& nbsp;Results: Tangeretin suppressed IL-1 beta-mediated inflammatory mediator secretion and degradation of ECM in chondrocytes. The results showed that tangeretin abrogated destabilized medial meniscus (DMM)-induced cartilage degradation in mice. Mechanistic studies showed that tangeretin suppressed OA development by downregulating activation of NF-kappa B by activating Nrf2/HO-1 axis and suppressing MAPK signaling pathway.& nbsp;Conclusion: Tangeretin abrogates OA progression by inhibiting inflammation as well as ECM degradation in chondrocytes and animal models. Effects of tangeretin are mediated through Nrf2/NF-kappa B and the MAPK/NF-kappa B pathways. Thus, tangeretin is a potential therapeutic agent for osteoarthritis treatment.
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