Journal
PHYTOCHEMISTRY LETTERS
Volume 49, Issue -, Pages 171-176Publisher
ELSEVIER
DOI: 10.1016/j.phytol.2022.03.006
Keywords
Paris polyphylla var; Yunnanensis; C27 Steroidal glycosides; Parisyunnanosides K and L; Cytotoxic activity
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Funding
- Sichuan Science and Technology Program [2017SZ0020]
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Chemical investigation of Paris polyphylla smith var. yunnanensis led to the discovery of two new polyhydroxylated steroidal glycosides, named Parisyunnanosides K and L (1-2), along with nine known compounds. The new compounds, Parisyunnanosides K and L (1-2), are rare C-27 steroidal glycosides. Furthermore, cytotoxic activity evaluation revealed that compounds 5-11 exhibited potent cytotoxic activity.
Chemical investigation of Paris polyphylla smith var. yunnanensis afforded two new polyhydroxylated steroidal glycosides, named Parisyunnanosides K and L (1-2), together with nine known ones. The chemical structures of the new compounds were elucidated by 1D, 2D NMR and HR-ESI-MS techniques, together with chemical methods. Parisyunnanosides K and L (1-2) are rare C-27 steroidal glycosides with two double bonds located at C-5, 6 and C-25, 26 of the aglycone, respectively. The cytotoxic activities of the isolated compounds were evaluated against Caco-2 cells by CCK-8 assay. Among them, compounds 5-11 exhibited potent cytotoxic activity with IC50 values ranging from 1.10 to 14.14 mu M compared with the positive control oxaliplatin (1.38 mu M).
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