Journal
PHYTOCHEMISTRY LETTERS
Volume 49, Issue -, Pages 192-196Publisher
ELSEVIER
DOI: 10.1016/j.phytol.2022.04.003
Keywords
Harrisonia perforate; Rutaceae; Chromones; Harriforatins; Anti-inflammatory activity
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Funding
- Thailand Science Research and Innovation Fund
- University of Phayao [FF65-RIM050, RSA5980010, FF64-UoE033]
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In this study, three new isoprenylated chromones were isolated from the stems of Harrisonia perforata, and two of them showed anti-inflammatory effects.
Three new isoprenylated chromones, named harriforatins A-C (1-3), along with 13 known compounds (4-16) were isolated from the stems of Harrisonia perforata. Their planar structures were elucidated by spectroscopic measurements. The experimental and calculated ECD curves were used to determine their absolute configurations. Most isolated compounds were evaluated for inflammation inhibition against lipopolysaccharide (LPS)induced nitric oxide (NO) production in RAW264.7 macrophages. Only compounds 5 and 6 showed inhibitory effects on NO production, with IC50 values of 42.8 and 47.0 mu M, respectively, that were stronger than that of the positive control, indomethacin (IC50 = 68.6 mu M).
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