Journal
PHYTOCHEMISTRY
Volume 198, Issue -, Pages -Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.phytochem.2022.113142
Keywords
Euphorbia neriifolia; Euphorbiaceae; Diterpenoid; Ent-abietane; Ent-kaurane; Ent-atisane; Ent-isopimarane; Phorneroids A-M; Cytotoxicity
Categories
Funding
- National Natural Science Foundation [81872758]
- CAMS Innovation Fund for Medical Sciences [2019I2M-5-080]
- Biological Resources Program of Chinese Academy of Sciences [KFJ-BRP-008-001]
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A chemical investigation on the aerial parts of Euphorbia neriifolia led to the discovery of thirteen undescribed diterpenoids, including phorneroid A, which features a unique structure. These compounds exhibited moderate cytotoxicity against two human tumor cell lines.
A chemical investigation on the aerial parts of Euphorbia neriifolia led to the identification of thirteen undescribed diterpenoids, phorneroids A-M, including ent-abietane (A-D), ent-kaurane (E-G), ent-atisane (H-K), and ent- isopimarane (L and M) types, together with three known compounds. Phorneroid A represents the first example of 8-spiro-fused 9,10-seco-ent-abietane diterpenoid lactone featuring a unique 6/5/6/5 spirocyclic framework. Biological assays showed that some of the compounds displayed moderate cytotoxicity against two human tumor cell lines, A549 and HL-60.
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