Journal
PHYTOCHEMISTRY
Volume 195, Issue -, Pages -Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.phytochem.2021.113057
Keywords
Agave desmetiana hort; Agavaceae; Cytotoxicity; Steroidal saponins; Tigogenin
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Three steroidal saponins were isolated from the leaves of Agave desmetiana hort, characterized and tested for cytotoxic activity, with one of the compounds showing the most potent cytotoxicity against tested cell lines.
Three steroidal saponins detected by LC-MS were isolated from the leaves of Agave desmetiana hort. The three saponins were characterized as; Tigogenin 3 - [{O - beta - D -xylopyranosyl (1 -> 2) - alpha - L-rhamnopyranosyl (1 -> 3)}-beta-D-glucopyranoside), Tigogenin- 3 - ([O-alpha-L-rhamnopyranosyl (1 -> 3) - beta - D -glalactopyranosyl (1 -> 2)] - beta - D - glucopyranoside) and Tigogenin- 3 -([{O - alpha - L - rhamnopyranosyl (1 -> 4)} - beta - D - gal-actopyranosyl (1 -> 3) - beta - D - xylopyranosyl (1 -> 2)] - beta - D - glucopyranoside). Identification and structure elucidation of the isolates were done via 1D and 2D NMR techniques, and chemical methods. Cytotoxic activity for the crude saponins and the three isolated compounds were evaluated against Hepg-2 and Mcf-7 cell lines. Compound 2 proved to be the most cytotoxic against tested cell lines with an IC50 2.97 and 2.49 mu g/ml respectively.
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