Journal
PHYSICS IN MEDICINE AND BIOLOGY
Volume 67, Issue 8, Pages -Publisher
IOP Publishing Ltd
DOI: 10.1088/1361-6560/ac5bfd
Keywords
FLASH; inverse compton scattering; radiobiology; ultra-high dose-rate
Funding
- Engineering and Physical Sciences Research Council [EP/P010059/1, EP/V049186/1]
- UKRI Future Leaders Fellowship [MR/T021721/1]
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A femtosecond-scale photon source based on inverse Compton scattering of laser-plasma accelerated electron beams is proposed to study the fundamental physical processes involved in radical production during irradiation in living tissue. This source can provide ultra-short and high-flux MeV-scale photon beams, offering the potential for time-resolved radiobiological experiments and advancements in radio-therapeutic techniques.
Objective. In the irradiation of living tissue, the fundamental physical processes involved in radical production typically occur on a timescale of a few femtoseconds. A detailed understanding of these phenomena has thus far been limited by the relatively long duration of the radiation sources employed, extending well beyond the timescales for radical generation and evolution. Approach. Here, we propose a femtosecond-scale photon source, based on inverse Compton scattering of laser-plasma accelerated electron beams in the field of a second scattering laser pulse. Main results. Detailed numerical modelling indicates that existing laser facilities can provide ultra-short and high-flux MeV-scale photon beams, able to deposit doses tuneable from a fraction of Gy up to a few Gy per pulse, resulting in dose rates exceeding 10(13) Gy/s. Significance. We envisage that such a source will represent a unique tool for time-resolved radiobiological experiments, with the prospect of further advancing radio-therapeutic techniques.
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