Journal
PHARMACOLOGICAL RESEARCH
Volume 177, Issue -, Pages -Publisher
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.phrs.2022.106131
Keywords
Estrogen; Anticancer drugs; Estrogen receptors; Metabolism; Precision therapy; Resistance
Categories
Funding
- National Key research and devel-opment Program of China [2021YFA0909500]
- Funda-mental Research Funds for the Central Universities, China [2042021gf0012]
- Natural Science Foundation of Hubei province, China [2019CFB416]
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This review summarizes the effects of estrogen on the targets, metabolism, and resistance of anticancer drugs and describes the related pathways and underlying mechanisms. Understanding the relationship between estrogen and cancer drug therapy is crucial for developing specific treatment strategies to achieve optimal outcomes.
Improving the efficacy of anticancer drugs is especially challenging. Estrogen is a sex hormone that not only promotes the development of female secondary sexual characteristics, but also supports many important physiological functions. Interestingly, estrogen has shown to be vital for the activity of some anticancer drugs, such as adriamycin, cisplatin, olaparib, trastuzumab, bevacizumab, tamoxifen, cyclophosphamide, methotrexate, and paclitaxel. Although there are many reasons for the differences in therapeutic effects among cancer patients, estrogen status is undoubtedly a very important factor. In view of the importance of the crosstalk between estrogen signaling and drug therapy for cancer, this review summarizes the effects of estrogen on the targets, metabolism and resistance of anticancer drugs and describes the related pathways and underlying mechanisms. Here, an analysis of the close relationship between estrogen and cancer drug therapy was conducted to clarify the effects of estrogen on the therapeutic efficacy of anticancer drugs to facilitate the future development of specific drug treatment strategies to achieve optimal outcomes.
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