4.7 Article

Traditional Chinese medicine use in the pathophysiological processes of intracerebral hemorrhage and comparison with conventional therapy

Related references

Note: Only part of the references are listed.
Article Clinical Neurology

Wogonin Accelerates Hematoma Clearance and Improves Neurological Outcome via the PPAR-γ Pathway After Intracerebral Hemorrhage

Jianfeng Zhuang et al.

Summary: Wogonin enhances phagocytosis, reduces inflammation, and oxidative stress, facilitating hematoma clearance and improving neurobehavioral recovery after ICH.

TRANSLATIONAL STROKE RESEARCH (2021)

Review Pharmacology & Pharmacy

Inhibiting ferroptosis: A novel approach for stroke therapeutics

Yizhen Jin et al.

Summary: This study reviews the therapeutic activity of inhibitors of ferroptosis in stroke models, summarizes previously reported neuroprotectants that show protective effects, and highlights the importance of ferroptosis during stroke processes.

DRUG DISCOVERY TODAY (2021)

Article Neurosciences

Memantine protects blood-brain barrier integrity and attenuates neurological deficits through inhibiting nitric oxide synthase ser1412 phosphorylation in intracerebral hemorrhage rats: involvement of peroxynitrite-related matrix metalloproteinase-9/NLRP3 inflammasome activation

Xiaowei Chen et al.

Summary: Memantine has shown neuroprotective effects in an intracerebral hemorrhage rat model by reducing phosphorylation of neuronal nitric oxide synthase ser(1412) and inhibiting peroxynitrite-related MMP-9 and NLRP3 inflammasome activation, leading to improvements in blood-brain barrier disruption and neurological deficits.

NEUROREPORT (2021)

Article Clinical Neurology

Molecular Correlates of Hemorrhage and Edema Volumes Following Human Intracerebral Hemorrhage Implicate Inflammation, Autophagy, mRNA Splicing, and T Cell Receptor Signaling

Marc Durocher et al.

Summary: This study identified peripheral blood genes and pathways associated with ICH and PHE volumes in human ICH patients. The inflammatory pathways, immune system genes, and hub genes enriched in neutrophil and T cell-specific genes may represent potential therapeutic targets for ICH outcomes.

TRANSLATIONAL STROKE RESEARCH (2021)

Article Biochemistry & Molecular Biology

Peroxynitrite activates NLRP3 inflammasome and contributes to hemorrhagic transformation and poor outcome in ischemic stroke with hyperglycemia

Hansen Chen et al.

Summary: Hyperglycemia exacerbates neuronal damage and poor outcomes in ischemic stroke, and peroxynitrite may play a key role in this process. Targeting peroxynitrite-mediated NLRP3 inflammasome activation could be a promising strategy for treating ischemic stroke with hyperglycemia.

FREE RADICAL BIOLOGY AND MEDICINE (2021)

Article Neurosciences

Neuroprotection of minocycline by inhibition of extracellular matrix metalloproteinase inducer expression following intracerebral hemorrhage in mice

Yang Liu et al.

Summary: The study demonstrates that minocycline plays a protective role in ICH by reducing EMMPRIN and MMP-9 expression, alleviating BBB disruption, inhibiting neuroinflammation, and decreasing neuronal degeneration and death.

NEUROSCIENCE LETTERS (2021)

Review Cell Biology

Mechanisms of Oxidative Stress and Therapeutic Targets following Intracerebral Hemorrhage

Zhenjia Yao et al.

Summary: This review provides an overview of the pathogenic mechanisms of brain injury following intracerebral hemorrhage and discusses the impact of oxidative stress on brain injury, as well as therapeutic strategies to mitigate brain injury.

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2021)

Review Medicine, Research & Experimental

Interleukin-6 signalling as a valuable cornerstone for molecular medicine (Review)

Maria Trovato et al.

Summary: Interleukin-6 (IL-6) has been studied for nearly 40 years for its biological capabilities, primarily in inflammatory and cognitive processes. It interacts with the IL-6 receptor complex and plays a crucial role in signal transduction. Abnormal production of IL-6 has been associated with diseases such as autoimmune thyroid disorders and SARS-CoV-2 infection.

INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE (2021)

Article Microbiology

Gut Microbiota Dysbiosis Induced by Intracerebral Hemorrhage Aggravates Neuroinflammation in Mice

Xiaobo Yu et al.

Summary: Intracerebral hemorrhage (ICH) can disrupt gut microbiota balance, leading to changes in immune responses and neuroinflammation. Restoring a healthy microbiota can alleviate functional deficits and neuroinflammation after ICH.

FRONTIERS IN MICROBIOLOGY (2021)

Article Pharmacology & Pharmacy

Baicalin Inhibits Ferroptosis in Intracerebral Hemorrhage

Lining Duan et al.

Summary: Intracerebral hemorrhage (ICH) is a subtype of stroke with high mortality and disability rates, where ferroptosis plays a dominant role in its pathogenesis. Baicalin, a main active ingredient of Chinese herbal medicine, exhibits neuroprotective effects against ICH-induced brain injury by inhibiting ferroptosis and shows potential as a therapeutic drug for ICH treatment.

FRONTIERS IN PHARMACOLOGY (2021)

Article Cell Biology

Puerarin attenuates intracerebral hemorrhage-induced early brain injury possibly by PI3K/Akt signal activation-mediated suppression of NF-κB pathway

Jun Zeng et al.

Summary: Puerarin (PUE) can significantly reduce neurological deficits and early brain injury (EBI) induced by intracerebral hemorrhage (ICH), possibly by activating the PI3K/Akt signal to inhibit the NF-kappa B pathway and regulate inflammation, oxidative stress, and apoptotic pathways.

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (2021)

Article Neurosciences

Perihematomal edema: Implications for intracerebral hemorrhage research and therapeutic advances

Magdy Selim et al.

JOURNAL OF NEUROSCIENCE RESEARCH (2020)

Article Neurosciences

Edaravone Administration Confers Neuroprotection after Experimental Intracerebral Hemorrhage in Rats via NLRP3 Suppression

Hongping Miao et al.

JOURNAL OF STROKE & CEREBROVASCULAR DISEASES (2020)

Review Cell Biology

Ferroptosis: past, present and future

Jie Li et al.

CELL DEATH & DISEASE (2020)

Review Clinical Neurology

Neuroinflammation after Intracerebral Hemorrhage and Potential Therapeutic Targets

Christine Tschoe et al.

JOURNAL OF STROKE (2020)

Review Medicine, Research & Experimental

Immune responses to stroke: mechanisms, modulation, and therapeutic potential

Costantino Iadecolar et al.

JOURNAL OF CLINICAL INVESTIGATION (2020)

Review Neurosciences

Programmed Cell Deaths and Potential Crosstalk With Blood-Brain Barrier Dysfunction After Hemorrhagic Stroke

Yuanjian Fang et al.

FRONTIERS IN CELLULAR NEUROSCIENCE (2020)

Article Pharmacology & Pharmacy

Danhong Injection Protects Hemorrhagic Brain by Increasing Peroxiredoxin 1 in Aged Rats

Shang Wang et al.

FRONTIERS IN PHARMACOLOGY (2020)

Review Cell Biology

The immune system and stroke: from current targets to future therapy

Kyle Malone et al.

IMMUNOLOGY AND CELL BIOLOGY (2019)

Review Medicine, General & Internal

Cerebral Intraparenchymal Hemorrhage A Review

Bradley A. Gross et al.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2019)

Article Health Care Sciences & Services

Tranexamic acid to improve functional status in adults with spontaneous intracerebral haemorrhage: the TICH-2 RCT

Nikola Sprigg et al.

HEALTH TECHNOLOGY ASSESSMENT (2019)

Article Clinical Neurology

Global brain inflammation in stroke

Kaibin Shi et al.

LANCET NEUROLOGY (2019)

Review Physiology

THE MICROBIOTA-GUT-BRAIN AXIS

John F. Cryan et al.

PHYSIOLOGICAL REVIEWS (2019)

Review Pharmacology & Pharmacy

Pathophysiological Mechanisms and Potential Therapeutic Targets in Intracerebral Hemorrhage

Zhiwei Shao et al.

FRONTIERS IN PHARMACOLOGY (2019)

Article Biochemistry & Molecular Biology

Peroxiredoxin 1/2 protects brain against H2O2-induced apoptosis after subarachnoid hemorrhage

Yue Lu et al.

FASEB JOURNAL (2019)

Review Clinical Neurology

Functional morphology of the blood-brain barrier in health and disease

Stefan Liebner et al.

ACTA NEUROPATHOLOGICA (2018)

Review Endocrinology & Metabolism

Brain endothelial cell junctions after cerebral hemorrhage: Changes, mechanisms and therapeutic targets

Richard F. Keep et al.

JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM (2018)

Review Clinical Neurology

Haemoglobin scavenging in intracranial bleeding: biology and clinical implications

Diederik Bulters et al.

NATURE REVIEWS NEUROLOGY (2018)

Article Neurosciences

Autophagy in hemorrhagic stroke: Mechanisms and clinical implications

Haiying Li et al.

PROGRESS IN NEUROBIOLOGY (2018)

Article Integrative & Complementary Medicine

Neuroprotective Effects of Magnesium Lithospermate B against Subarachnoid Hemorrhage in Rats

Yucong Peng et al.

AMERICAN JOURNAL OF CHINESE MEDICINE (2018)

Article Biochemistry & Molecular Biology

MiR-590-5p alleviates intracerebral hemorrhage-induced brain injury through targeting Peli1 gene expression

Qiang Guo et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2018)

Article Neurosciences

Coagulation Profile after Spontaneous Intracerebral Hemorrhage: A Cohort Study

Signe Voigt Lauridsen et al.

JOURNAL OF STROKE & CEREBROVASCULAR DISEASES (2018)

Review Neurosciences

Programmed Cell Death after Intracerebral Hemorrhage

Tobias Bobinger et al.

CURRENT NEUROPHARMACOLOGY (2018)

Article Biochemistry & Molecular Biology

Lactate potentiates angiogenesis and neurogenesis in experimental intracerebral hemorrhage

Jing Zhou et al.

EXPERIMENTAL AND MOLECULAR MEDICINE (2018)

Article Clinical Neurology

RIP1 and RIP3 mediate hemin-induced cell death in HT22 hippocampal neuronal cells

Xingfen Su et al.

NEUROPSYCHIATRIC DISEASE AND TREATMENT (2018)

Review Clinical Neurology

Brain-gut axis after stroke

Awadhesh K. Arya et al.

BRAIN CIRCULATION (2018)

Article Clinical Neurology

Early Erythrolysis in the Hematoma After Experimental Intracerebral Hemorrhage

Ge Dang et al.

TRANSLATIONAL STROKE RESEARCH (2017)

Article Endocrinology & Metabolism

Neuroprotection of brain-permeable iron chelator VK-28 against intracerebral hemorrhage in mice

Qian Li et al.

JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM (2017)

Article Oncology

Protective role of microRNA-126 in intracerebral hemorrhage

Fangen Kong et al.

MOLECULAR MEDICINE REPORTS (2017)

Article Biochemistry & Molecular Biology

P2X7 Participates in Intracerebral Hemorrhage-Induced Secondary Brain Injury in Rats via MAPKs Signaling Pathways

Zunjia Wen et al.

NEUROCHEMICAL RESEARCH (2017)

Article Integrative & Complementary Medicine

An Investigation of the Use of Traditional Chinese Medicine and Complementary and Alternative Medicine in Stroke Patients

Mei-Ling Yeh et al.

HOLISTIC NURSING PRACTICE (2017)

Review Clinical Neurology

Epidemiology, Risk Factors, and Clinical Features of Intracerebral Hemorrhage: An Update

Sang Joon An et al.

JOURNAL OF STROKE (2017)

Article Biochemistry & Molecular Biology

MicroRNA-126-3p attenuates blood-brain barrier disruption, cerebral edema and neuronal injury following intracerebral hemorrhage by regulating PIK3R2 and Akt

Tianyang Xi et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2017)

Article Medicine, Research & Experimental

Silymarin prevents NLRP3 inflammasome activation and protects against intracerebral hemorrhage

Raorao Yuan et al.

BIOMEDICINE & PHARMACOTHERAPY (2017)

Article Endocrinology & Metabolism

Inhibition of prostaglandin E2 receptor EP3 mitigates thrombin-induced brain injury

Xiaoning Han et al.

JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM (2016)

Article Hematology

Activation of the NLRP3 inflammasome by cellular labile iron

Kyohei Nakamura et al.

EXPERIMENTAL HEMATOLOGY (2016)

Article Neurosciences

Microbiota Dysbiosis Controls the Neuroinflammatory Response after Stroke

Vikramjeet Singh et al.

JOURNAL OF NEUROSCIENCE (2016)

Article Clinical Neurology

Minocycline is effective in intracerebral hemorrhage by inhibition of apoptosis and autophagy

Zehan Wu et al.

JOURNAL OF THE NEUROLOGICAL SCIENCES (2016)

Review Cell Biology

Oxidative Stress in Intracerebral Hemorrhage: Sources, Mechanisms, and Therapeutic Targets

Xin Hu et al.

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2016)

Review Cell Biology

Intracerebral Hemorrhage, Oxidative Stress, and Antioxidant Therapy

Xiaochun Duan et al.

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2016)

Article Medicine, Research & Experimental

Rhubarb attenuates blood-brain barrier disruption via increased zonula occludens-1 expression in a rat model of intracerebral hemorrhage

Yang Wang et al.

EXPERIMENTAL AND THERAPEUTIC MEDICINE (2016)

Review Medicine, Research & Experimental

Transcriptomics: a sword to cut the Gordian knot of traditional Chinese medicine

Yufeng Liu et al.

BIOMARKERS IN MEDICINE (2015)

Article Biochemistry & Molecular Biology

Necrostatin-1 Ameliorates Intracerebral Hemorrhage-Induced Brain Injury in Mice Through Inhibiting RIP1/RIP3 Pathway

Xingfen Su et al.

NEUROCHEMICAL RESEARCH (2015)

Article Biochemistry & Molecular Biology

Cleaning up after ICH: the role of Nrf2 in modulating microglia function and hematoma clearance

Xiurong Zhao et al.

JOURNAL OF NEUROCHEMISTRY (2015)

Article Clinical Neurology

Microglial and macrophage polarization -new prospects for brain repair

Xiaoming Hu et al.

NATURE REVIEWS NEUROLOGY (2015)

Review Clinical Neurology

Edaravone for acute stroke: Meta-analyses of data from randomized controlled trials

Jie Yang et al.

DEVELOPMENTAL NEUROREHABILITATION (2015)

Article Clinical Neurology

NLRP3 inflammasome contributes to inflammation after intracerebral hemorrhage

Qingyi Ma et al.

ANNALS OF NEUROLOGY (2014)

Article Cell Biology

Baicalin Attenuates Brain Edema in a Rat Model of Intracerebral Hemorrhage

Qing-Bo Zhou et al.

INFLAMMATION (2014)

Article Medicine, General & Internal

Astragaloside IV Alleviates Early Brain Injury Following Experimental Subarachnoid Hemorrhage in Rats

Anwen Shao et al.

INTERNATIONAL JOURNAL OF MEDICAL SCIENCES (2014)

Review Endocrinology & Metabolism

Hemorrhagic transformation after ischemic stroke in animals and humans

Glen C. Jickling et al.

JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM (2014)

Review Neurosciences

Vascular disruption and blood-brain barrier dysfunction in intracerebral hemorrhage

Richard F. Keep et al.

FLUIDS AND BARRIERS OF THE CNS (2014)

Review Biochemistry & Molecular Biology

Cerebral cavernous malformations: from CCM genes to endothelial cell homeostasis

Andreas Fischer et al.

TRENDS IN MOLECULAR MEDICINE (2013)

Article Clinical Neurology

Nrf2 to Pre-condition the Brain Against Injury Caused by Products of Hemolysis After ICH

Xiurong Zhao et al.

TRANSLATIONAL STROKE RESEARCH (2013)

Review Biochemistry & Molecular Biology

Wnt/β-Catenin Signaling and Disease

Hans Clevers et al.

Article Plant Sciences

The protective role of oxymatrine on neuronal cell apoptosis in the hemorrhagic rat brain

Man Huang et al.

JOURNAL OF ETHNOPHARMACOLOGY (2012)

Article Medicine, General & Internal

Hyperosmolar Therapy for Raised Intracranial Pressure

Allan H. Ropper

NEW ENGLAND JOURNAL OF MEDICINE (2012)

Article Clinical Neurology

Inhibition of Carbonic Anhydrase Reduces Brain Injury After Intracerebral Hemorrhage

Fuyou Guo et al.

TRANSLATIONAL STROKE RESEARCH (2012)

Article Pharmacology & Pharmacy

Management of Unruptured Intracranial Aneurysms and Arteriovenous Malformations

Maggie L. McNulty et al.

AMERICAN JOURNAL OF THERAPEUTICS (2011)

Review Pharmacology & Pharmacy

Cytokine Signaling Modulates Blood-Brain Barrier Function

Weihong Pan et al.

CURRENT PHARMACEUTICAL DESIGN (2011)

Review Biochemistry & Molecular Biology

The role of free radical generation in increasing cerebrovascular permeability

Paul A. Fraser

FREE RADICAL BIOLOGY AND MEDICINE (2011)

Article Clinical Neurology

Neutrophil Depletion Reduces Blood-Brain Barrier Breakdown, Axon Injury, and Inflammation After Intracerebral Hemorrhage

Iska Moxon-Emre et al.

JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY (2011)

Article Pharmacology & Pharmacy

Treatment with Z-Ligustilide, a Component of Angelica sinensis, Reduces Brain Injury after a Subarachnoid Hemorrhage in Rats

Di Chen et al.

JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2011)

Article Clinical Neurology

Blood Brain Barrier Breakdown and Repair by Src after Thrombin-Induced Injury

Da-Zhi Liu et al.

ANNALS OF NEUROLOGY (2010)

Article Neurosciences

Effects of Aquaporin-4 on edema formation following intracerebral hemorrhage

Yuping Tang et al.

EXPERIMENTAL NEUROLOGY (2010)

Article Cardiac & Cardiovascular Systems

EPHB4 Gene Polymorphisms and Risk of Intracranial Hemorrhage in Patients With Brain Arteriovenous Malformations

Shantel Weinsheimer et al.

CIRCULATION-CARDIOVASCULAR GENETICS (2009)

Article Cell Biology

Activation of TLR4-Mediated NF kappa B Signaling in Hemorrhagic Brain in Rats

Weiyu Teng et al.

MEDIATORS OF INFLAMMATION (2009)

Article Cell Biology

Wnt/β-catenin signaling controls development of the blood-brain barrier

Stefan Liebner et al.

JOURNAL OF CELL BIOLOGY (2008)

Article Biochemistry & Molecular Biology

Role of Nrf2 in protection against intracerebral hemorrhage injury in mice

Jian Wang et al.

FREE RADICAL BIOLOGY AND MEDICINE (2007)

Review Biochemistry & Molecular Biology

Brain iron toxicity: Differential responses of astrocytes, neurons, and endothelial cells

Julie A. Gaasch et al.

NEUROCHEMICAL RESEARCH (2007)

Review Pharmacology & Pharmacy

Osmotherapy for elevated intracranial pressure - A critical reappraisal

R Nau

CLINICAL PHARMACOKINETICS (2000)