Journal
PHARMACOLOGICAL RESEARCH
Volume 179, Issue -, Pages -Publisher
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.phrs.2022.106200
Keywords
Intracerebral hemorrhage (ICH); Brain injury; Pathophysiology; Mechanism; Traditional Chinese medicines (TCM)
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Funding
- National Natural Science Foundation of China [81973792, 82004331]
- Innovation Team and Talents Cultivation Program of National Administration of Traditional Chinese Medicine [ZYYCXTD-C-202009]
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This paper summarizes the mechanisms by which traditional Chinese medicine improves cerebral injury after intracerebral hemorrhage (ICH) and compares them with conventional Western medicine. The findings provide clues and references for the clinical application of traditional Chinese medicine in the prevention and treatment of hemorrhagic stroke and the development of new drugs.
Intracerebral hemorrhage (ICH) refers to hemorrhage caused by non-traumatic vascular rupture in the brain parenchyma, which is characterized by acute onset, severe illness, and high mortality and disability. The influx of blood into the brain tissue after cerebrovascular rupture causes severe brain damage, including primary injury caused by persistent hemorrhage and secondary brain injury (SBI) induced by hematoma. The mechanism of brain injury is complicated and is a significant cause of disability after ICH. Therefore, it is essential to understand the mechanism of brain injury after ICH to develop drugs to prevent and treat ICH. Studies have confirmed that many traditional Chinese medicines (TCM) can reduce brain injury by improving neurotoxicity, inflammation, oxidative stress (OS), blood-brain barrier (BBB), apoptosis, and neurological dysfunction after ICH. Starting from the pathophysiological process of brain injury after ICH, this paper summarizes the mechanisms by which TCM improves cerebral injury after ICH and its comparison with conventional western medicine, so as to provide clues and a reference for the clinical application of TCM in the prevention and treatment of hemorrhagic stroke and further research and development of new drugs.
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