Neuroimaging Findings in Parechovirus Encephalitis: A Case Series of Pediatric Patients

Article Clinical Neurology

HPeV3-associated acute encephalitis/encephalopathy among Japanese infants

Yuichi Abe et al.

Summary: This study aimed to compare the clinical characteristics of human parechovirus type 3 (HPeV3) associated acute encephalitis/encephalopathy (HPeV3E/E) between infants with abnormal and normal brain MRI findings. The results showed no significant differences in lab results or symptoms between the two groups, except for gastrointestinal symptoms present only in the MRI-negative patients.

BRAIN & DEVELOPMENT (2021)

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Article Microbiology

Emergence of Parechovirus A3 as the Leading Cause of Central Nervous System Infection, Surpassing Any Single Enterovirus Type, in Children in Kansas City, Missouri, USA, from 2007 to 2016

Anjana Sasidharan et al.

Summary: A study on pediatric central nervous system infections in the United States found that picornaviruses, such as EV and PeV-A, were the most common causes, with PeV-A3 being the dominant type. The detection of multiple EV and two PeV-A types in children's cerebrospinal fluid suggests routine testing and reporting of PeV-A, especially in infants under 6 months old. This could help reduce hospital stays and antibiotic usage in young children with acute febrile illnesses.

JOURNAL OF CLINICAL MICROBIOLOGY (2021)

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Article Immunology

Childhood Outcomes Following Parechovirus Infections in a US Young Infant Cohort

Howard Kilbride et al.

Summary: In this US cohort, approximately 11% of infants with PeV-A3 infection showed neurodevelopmental impairment at 3 years of age. Parental concerns were frequently identified. Longitudinal developmental monitoring is necessary.

PEDIATRIC INFECTIOUS DISEASE JOURNAL (2021)

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Article Pediatrics