4.5 Article

Temporal Association between Influenza Vaccination Coverage and Ambulatory Antibiotic Use in Children

Journal

PEDIATRIC INFECTIOUS DISEASE JOURNAL
Volume 41, Issue 7, Pages 600-602

Publisher

LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/INF.0000000000003533

Keywords

antibiotics; antibiotic stewardship; epidemiology; influenza vaccination

Funding

  1. federal grant (Epidemiology and Laboratory Capacity Project K2) from the Centers for Disease Control and Prevention

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This population-based retrospective cohort study found that increased influenza vaccination coverage was temporally associated with a decrease in ambulatory antibiotic use in children. After adjusting for yearly vaccine effectiveness, the antibiotic prescription rate decreased by 3/1000 person-months for each 1% increase in influenza vaccination coverage between 2012 and 2017 in South Carolina (P < 0.001).
In this population-based retrospective cohort study, increased influenza vaccination coverage was temporally associated with a reduction in ambulatory antibiotic use in children. After adjustment for yearly vaccine effectiveness, antibiotic prescription rate declined by 3/1000 person-months for each 1% increase in influenza vaccination coverage between 2012 and 2017 in South Carolina (P < 0.001).

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