4.4 Article

A validated high-throughput method for assaying rat lungworm (Angiostrongylus cantonensis) motility when challenged with potentially anthelmintic natural products from Hawaiian fungi

Related references

Note: Only part of the references are listed.
Article Parasitology

Guidelines for the diagnosis and treatment of neuroangiostrongyliasis: updated recommendations

Vernon Ansdell et al.

Summary: This paper reviews the preliminary guidelines for the diagnosis and treatment of neuroangiostrongyliasis developed by a subcommittee of the Hawaii Governor's Joint Task Force on Rat Lungworm Disease in 2018. It discusses the diagnostic process for NAS using real-time polymerase chain reaction (RTi-PCR) and the recommended treatments with corticosteroids and albendazole. Additionally, long-term sequelae of NAS are explored and suggestions for future research are proposed.

PARASITOLOGY (2021)

Article Veterinary Sciences

First Documented Cases of Canine Neuroangiostrongyliasis Due to Angiostrongylus cantonensis in Hawaii

Jenee Odani et al.

Summary: Two young dogs in Honolulu, Hawaii presented with neurologic symptoms related to spinal cord disease, and were diagnosed with neuroangiostrongyliasis. Both dogs responded well to treatment and made a complete recovery. These are the first confirmed cases of autochthonous neuroangiostrongyliasis in canine patients in the United States, and the first dogs anywhere to be definitively diagnosed with A cantonensis infection based on real-time polymerase chain reaction testing of CSF.

JOURNAL OF THE AMERICAN ANIMAL HOSPITAL ASSOCIATION (2021)

Article Biochemistry & Molecular Biology

Antibacterial kaneoheoic acids A-F from a Hawaiian fungus Fusarium sp. FM701

K. H. Ahammad Uz Zaman et al.

Summary: Six previously unidentified fungal polyketides were isolated from a fungal strain collected from Hawaiian beach, showing significant antibacterial activity against Staphylococcus aureus and Bacillus subtilis when tested in combination with either an FDA approved antibiotic or an established antibiotic adjuvant. This study highlights the potential of developing new antibiotic molecules from underexplored sources and utilizing alternative approaches to combat antibiotic resistance.

PHYTOCHEMISTRY (2021)

Review Pharmacology & Pharmacy

Drug discovery: Insights from the invertebrate Caenorhabditis elegans

Sebastian Giunti et al.

Summary: This review highlights the reasons why Caenorhabditis elegans is positioned as an outstanding cost-effective option for drug discovery, as well as the advantages and drawbacks of this model. The suitability of C. elegans in large-scale genetic and pharmacological screenings is emphasized, and its high-throughput screenings have contributed to the breakthrough of various candidate compounds involved in extensive fields.

PHARMACOLOGY RESEARCH & PERSPECTIVES (2021)

Article Biochemistry & Molecular Biology

Aspochalasin H1: A New Cyclic Aspochalasin from Hawaiian Plant-Associated Endophytic Fungus Aspergillus sp. FT1307

Mallique Qader et al.

Summary: A new compound, aspochalasin H1, with unique structural features, was isolated from Aspergillus sp. FT1307. The isolated compounds showed diverse biological activities against pathogenic bacteria and cancer cell lines.

MOLECULES (2021)

Review Microbiology

Development of emodepside as a possible adulticidal treatment for human onchocerciasis-The fruit of a successful industrial-academic collaboration

Jurgen Kruecken et al.

Summary: Current mass drug administration programs for river blindness rely on ivermectin but fail to eliminate adult worms. Emodepside, a broad-spectrum anthelmintic used in veterinary medicine, is considered a promising candidate for the treatment of onchocerciasis. Collaboration between academia and the pharmaceutical industry has led to Phase I clinical trials demonstrating the safety and efficacy of emodepside as an adulticide against the closely related cattle parasite Onchocerca ochengi, with Phase II trials planned for human health benefits.

PLOS PATHOGENS (2021)

Review Parasitology

An appraisal of natural products active against parasitic nematodes of animals

Jose F. Garcia-Bustos et al.

PARASITES & VECTORS (2019)

Article Public, Environmental & Occupational Health

Neuroangiostrongyliasis: The Subarachnoid Phase and Its Implications for Anthelminthic Therapy

Paul Prociv et al.

AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE (2018)

Article Chemistry, Multidisciplinary

Biosynthesis of Heptacyclic Duclauxins Requires Extensive Redox Modifications of the Phenalenone Aromatic Polyketide

Shu-Shan Gao et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2018)

Article Infectious Diseases

Unique pharmacological properties of serotoninergic G-protein coupled receptors from cestodes

Federico Camicia et al.

PLOS NEGLECTED TROPICAL DISEASES (2018)

Review Parasitology

Anthelmintic drugs used in equine species

Cengiz Gokbulut et al.

VETERINARY PARASITOLOGY (2018)

Review Parasitology

The population genetics of parasitic nematodes of wild animals

Rebecca Cole et al.

PARASITES & VECTORS (2018)

Article Multidisciplinary Sciences

Neurodegeneration in C-elegans models of ALS requires TIR-1/Sarm1 immune pathway activation in neurons

Julie Veriepe et al.

NATURE COMMUNICATIONS (2015)

Article Immunology

Geographic Range Expansion for the Rat Lungworm in North America

Emily M. York et al.

EMERGING INFECTIOUS DISEASES (2015)

Article Parasitology

The nervous and prenervous roles of serotonin in Echinococcus spp.

F. Camicia et al.

INTERNATIONAL JOURNAL FOR PARASITOLOGY (2013)

Review Plant Sciences

Top 10 plant-parasitic nematodes in molecular plant pathology

John T. Jones et al.

MOLECULAR PLANT PATHOLOGY (2013)

Review Parasitology

New advancement in anthelmintic drugs in veterinary medicine

Christian Epe et al.

TRENDS IN PARASITOLOGY (2013)

Review Multidisciplinary Sciences

Ivermectin, 'Wonder drug' from Japan: the human use perspective

Andy Crump et al.

PROCEEDINGS OF THE JAPAN ACADEMY SERIES B-PHYSICAL AND BIOLOGICAL SCIENCES (2011)

Review Medicine, Research & Experimental

Helminth infections: the great neglected tropical diseases

Peter J. Hotez et al.

JOURNAL OF CLINICAL INVESTIGATION (2008)

Article Multidisciplinary Sciences

Homage to Linnaeus: How many parasites? How many hosts?

Andy Dobson et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)

Article Biochemical Research Methods

An automated tracking system for Caenorhabditis elegans locomotor behavior and circadian studies application

Sergio H. Simonetta et al.

JOURNAL OF NEUROSCIENCE METHODS (2007)

Review Plant Sciences

Parasitic nematode interactions with mammals and plants

DP Jasmer et al.

ANNUAL REVIEW OF PHYTOPATHOLOGY (2003)

Article Parasitology

Caenorhabditis elegans:: how good a model for veterinary parasites?

TG Geary et al.

VETERINARY PARASITOLOGY (2001)