On the diagnosis of pain in Parkinson disease: a mechanism-based approach

Article Anesthesiology

The Parkinson disease pain classification system: results from an international mechanism-based classification approach

Veit Mylius et al.

Summary: This study developed a framework to differentiate Parkinson disease (PD)-related pain from unrelated pain, classifying PD-related pain into different types based on mechanistic pain descriptors. The PD-Pain Classification System (PD-PCS) was found to be a valid and reliable tool for distinguishing PD-related pain from unrelated pain.

PAIN (2021)

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Review Anesthesiology

Pain in the neurodegenerating brain: insights into pharmacotherapy for Alzheimer disease and Parkinson disease

Timothy Lawn et al.

PAIN (2021)

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Review Geriatrics & Gerontology

Diagnosis and Management of Pain in Parkinson's Disease: A New Approach

Veit Mylius et al.

Summary: Pain in Parkinson's disease is a common and disabling non-motor symptom. The PD Pain Classification System allows for a more targeted treatment approach based on the underlying pain mechanism. Optimizing dopaminergic therapy is suggested as the initial step in treatment, with consideration of alternative causes of pain if initial treatments are unsuccessful. Further treatment options, including drugs, invasive treatments, and physiotherapy, are discussed with a focus on elderly PD patients and the potential impacts of polypharmacy, altered pharmacokinetics, and comorbidities.

DRUGS & AGING (2021)

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Article Clinical Neurology