Oxidative Stress-Related Mechanisms in SARS-CoV-2 Infections

The COVID-19 pandemic caused relatively high mortality in patients, especially in those with concomitant diseases (i.e., diabetes, hypertension, and chronic obstructive pulmonary disease (COPD)). In most of aforementioned comorbidities, the oxidative stress appears to be an important player in their pathogenesis. The direct cause of death in critically ill patients with COVID-19 is still far from being elucidated. Although some preliminary data suggests that the lung vasculature injury and the loss of the functioning part of pulmonary alveolar population are crucial, the precise mechanism is still unclear. On the other hand, at least two classes of medications used with some clinical benefits in COVID-19 treatment seem to have a major influence on ROS (reactive oxygen species) and RNS (reactive nitrogen species) production. However, oxidative stress is one of the important mechanisms in the antiviral immune response and innate immunity. Therefore, it would be of interest to summarize the data regarding the oxidative stress in severe COVID-19. In this review, we discuss the role of oxidative and antioxidant mechanisms in severe COVID-19 based on available studies. We also present the role of ROS and RNS in other viral infections in humans and in animal models. Although reactive oxygen and nitrogen species play an important role in the innate antiviral immune response, in some situations, they might have a deleterious effect, e.g., in some coronaviral infections. The understanding of the redox mechanisms in severe COVID-19 disease may have an impact on its treatment.

Automated summary

The COVID-19 pandemic has resulted in high mortality, particularly in patients with comorbidities such as diabetes, hypertension, and COPD. Oxidative stress is believed to play a significant role in the pathogenesis of these comorbidities. Although the exact mechanism of death in critically ill COVID-19 patients is still unclear, lung vasculature injury and loss of lung function are considered crucial. Medications used in COVID-19 treatment that influence reactive oxygen and nitrogen species production may be beneficial. However, oxidative stress is also involved in antiviral immune response, and understanding the redox mechanisms in severe COVID-19 could impact its treatment.