Journal
OSTEOARTHRITIS AND CARTILAGE
Volume 30, Issue 5, Pages 756-764Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.joca.2022.02.616
Keywords
Osteoarthritis; Biomarkers; Magnetic resonance imaging (MRI); Cartilage degradation; Metalloproteinase
Categories
Funding
- International Graduate Research Scholarship, University of Tasmania
- National Health and Medical Research Council of Australia Fellowship
- National Health and Medical Research Council [211316, 490006, 1128373]
- Royal Hobart Hospital Research Foundation (RHHRF) [18-202 RHHRF]
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The study found that levels of COMP and MMP-3 were negatively associated with knee cartilage thickness and volume, and MRI markers assessed at different time points were also correlated with biochemical markers.
Objective: To describe the associations between osteoarthritis (OA)-related biochemical markers (COMP, MMP-3, HA) and MRI-based imaging biomarkers in middle-aged adults over 10-13 years. Methods: Blood serum samples collected during the Childhood Determinants of Adult Health (CDAH)-1 study (year:2004-06; n = 156) and 10-13 year follow-up at CDAH-3 (n = 167) were analysed for COMP, MMP-3, and HA using non-isotopic ELISA. Knee MRI scans obtained during the CDAH-knee study (year:2008-10; n = 313) were assessed for cartilage volume and thickness, subchondral bone area, cartilage defects, and BML. Results: In a multivariable linear regression model describing the association of baseline biochemical markers with MRI-markers (assessed after 4-years), we found a significant negative association of standardised COMP with medial femorotibial compartment cartilage thickness (beta:-0.070; 95%CI:-0.138,-0.001), and standardised MMP-3 with patellar cartilage volume (beta:-141.548; 95%CI:-254.917,-28.179) and total bone area (beta:-0.729; 95%CI:-1.340,-0.118). In multivariable Tobit regression model, there was a significant association of MRI-markers with biochemical markers (assessed after 6-9 years); a significant negative association of patellar cartilage volume (beta:-0.001; 95%CI:-0.002,-0.00004), and total bone area (beta:-0.158; 95%CI-0.307,-0.010) with MMP-3, and total cartilage volume (beta:-0.001; 95%CI:-0.001,-0.0001) and total bone area (beta:-0.373; 95%CI:-0.636,-0.111) with COMP. No significant associations were observed between MRI-based imaging biomarkers and HA. Conclusion: COMP and MMP-3 levels were negatively associated with knee cartilage thickness and volume assessed 4-years later, respectively. Knee cartilage volume and bone area were negatively associated with COMP and MMP-3 levels assessed 6-9 years later. These results suggest that OA-related biochemical markers and MRI-markers are interrelated in early OA. (C) 2022 Osteoarthritis Research Society International. Published by Elsevier Ltd. All rights reserved.
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