Journal
ORGANIC LETTERS
Volume 24, Issue 14, Pages 2679-2683Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.2c00763
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Funding
- National Natural Science Foundation of China [22001096]
- Natural Science Foundation of Zhejiang Province [LQ21B020008]
- Start Up Funds of Jiaxing University [CD70519040]
- Jiaxing University Hundred Youth Training Talents [CD70621018]
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In this study, a distinctive photoredox/copper dual-catalyzed esterification of benzylic C-H bonds was reported, which involves the combination of photoredox-mediated hydrogen atom transfer and Cu(II)-mediated radical-polar crossover. The methodology shows a high functional group tolerance (>40 examples) and moderate to good yields with structurally diverse benzylic C-H substrates. Notably, stoichiometric amounts of carboxylic acids are used as coupling partners, enabling the synthesis of structurally diverse benzylic esters and the late-stage functionalization of pharmaceuticals.
Herein, we report a distinctive photoredox/copper dual-catalyzed esterification of benzylic C-H bonds through the combination of photoredox-mediated hydrogen atom transfer and Cu(II)-mediated radical-polar crossover. This methodology demonstrates a high functional group tolerance (>40 examples) and moderate to good yields with structurally diverse benzylic C-H substrates. Notably, stoichiometric amounts of carboxylic acids are used as coupling partners, which allows the synthesis of structurally diverse benzylic esters and the late-stage functionalization of pharmaceuticals.
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