Journal
ORGANIC LETTERS
Volume 24, Issue 18, Pages 3325-3330Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.2c00871
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Funding
- Research Center for Computational Science, Okazaki, Japan [21-IMS-C123]
- JSPS [JP19J23157]
- JSPS KAKENHI [JP18H04239, JP18K06545, JP21H05077, JP17H06442]
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Selective C(sp(3))-H functionalization using photoredox catalysis and hydrogen atom transfer catalysis has attracted increasing attention. We report the use of a Ph2GeCl2 cocatalyst that greatly improves the yield of alpha-C(sp(3))-H alkylation of primary amines catalyzed by a PC-HAT hybrid system. The alpha-position of the amino group selectively reacts, even when weaker C-H bonds exist in the substrates. This finding may aid in the design of novel site-selective hybrid catalysis.
Site-selective C(sp(3))-H functionalizations using photoredox catalysis (PC) and hydrogen atom transfer (HAT) catalysis have received increasing attention. Here, we report a Ph2GeCl2 cocatalyst that greatly improves the yield of alpha-C(sp(3))-H alkylation of primary amines catalyzed by a PC-HAT hybrid system. The alpha-position of the amino group selectively reacted even when weaker C-H bonds existed in the substrates. This finding may help the design of a novel site-selective hybrid catalysis.
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