Synthesis of Secondary Trifluoromethylated Alkyl Bromides Using 2-Bromo-3,3,3-trifluoropropene as a Radical Acceptor

Herein, the first example using commercially available 2-bromo-3,3,3-trifluoropropene (BTP) as a radical acceptor has been reported. Taking advantage of this strategy, a wide range of secondary trifluoromethylated alkyl bromides were synthesized in good to excellent yields with broad functional group tolerance by using redox-active esters as a radical precursor. The practicality of this protocol was further demonstrated by diverse derivations and direct modification of biologically active molecules.

Automated summary

This study reports the first example of using commercially available 2-bromo-3,3,3-trifluoropropene as a radical acceptor to synthesize secondary trifluoromethylated alkyl bromides. The practicality of this method was further demonstrated by diverse derivations and direct modification of biologically active molecules.