Journal
ORGANIC LETTERS
Volume 24, Issue 14, Pages 2722-2727Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.2c00826
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Funding
- National Natural Science Foundation of China [21672024, 21272026, 21871029]
- Beijing Natural Science Foundation [2182025]
- Shanghai Key Laboratory for Molecular Engineering of Chiral Drugs
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A highly efficient asymmetric hydrogenation method has been developed for the synthesis of chiral gamma-hydroxy acid derivatives. The method shows excellent enantioselectivity and has the potential to be applied in the synthesis of chiral compounds and key intermediates for pharmaceutical synthesis.
A highly efficient asymmetric hydrogenation of a series of gamma-keto acid derivatives, including gamma-keto acids, esters, andamides, using a Ni-(R,R)-QuinoxP*complex as the catalyst has been developed to afford chiral gamma-hydroxy acid derivatives withexcellent enantioselectivities, up to 99.9% ee. This method provides not only an economical one-pot approach for the synthesis ofchiral gamma-lactones but also access to (S)-norfluoxetine, an inhibitor of neural serotonin reuptake and an essential intermediate forpharmaceutical synthesis.
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