Journal
ORGANIC LETTERS
Volume 24, Issue 22, Pages 4029-4033Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.2c01462
Keywords
-
Categories
Funding
- CNRS
- Institut Polytechnique de Paris (IP Paris)
- Ecole Polytechnique
- Sorbonne Universite (SU)
- IP Paris
- SU
Ask authors/readers for more resources
This study presents the shortest synthesis method for radulanin A to date, utilizing a less explored photochemical ring expansion reaction. The method has been adapted for larger-scale preparation, enabling biological investigations into the herbicidal properties of this natural product.
The radulanins are biologically active bibenzyl natural products featuring a synthetically challenging 2,5-dihydro-1-benzoxepine core. In contrast with previous reports exhibiting lengthy strategies, we demonstrate the shortest synthesis of radulanin A to date, featuring a largely unexplored photochemical ring expansion reaction of a 2,2-dimethylchromene precursor. This work was adapted to a continuous-flow setup for larger-scale preparation, in view of biological investigations into the herbicidal properties of this natural product.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available