Journal
ORGANIC LETTERS
Volume 24, Issue 22, Pages 3998-4002Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.2c01408
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Funding
- University of Wisconsin-Madison School of Pharmacy
- NIH through the administration of NIAID [U19AI109673, U19AI142720]
- University of Wisconsin Carbone Cancer Center Support Grant [P30 CA014520]
- UW2020 grant from the Wisconsin Alumni Research Foundation
- NIH [P41GM103399]
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In this study, a novel marine-derived siderophore, Pseudonochelin (1), was discovered using genome mining and metabolomics technologies. It was found that 1 contained a previously unidentified 5-aminosalicylic acid unit. Through annotation of a putative biosynthetic gene cluster and bioinformatics analysis, the biosynthesis of 1 was proposed. Furthermore, 1 exhibited iron-dependent antibacterial activity both in vitro and in vivo.
Pseudonochelin (1), a siderophore from a marine-derived Pseudonocardia sp. bacterium, was discovered using genome mining and metabolomics technologies. A 5-aminosalicylic acid (5-ASA) unit, not previously found in siderophore natural products, was identified in 1. Annotation of a putative psn biosynthetic gene cluster combined with bioinformatics and isotopic enrichment studies enabled us to propose the biosynthesis of 1. Moreover, 1 was found to display in vitro and in vivo antibacterial activity in an iron-dependent fashion.
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