Super-Electron-Donor 2-Azaallyl Anions Enable Construction of Isoquinolines

Herein is introduced the application of superelectron-donor(SED) 2-azaallyl anions in a tandem reduction/radical cyclization/radical coupling/aromatization protocol that enables the rapid construction of isoquinolines. The value of this transition-metal-free method is highlighted by the wide range of isoquinoline ethyl amines prepared with good functional group tolerance and yields. An operationally simple gram scale synthesis is also conducted, confirming the scalability.

Automated summary

This study introduces a transition-metal-free method using superelectron-donor for the rapid construction of isoquinolines through a tandem reaction, demonstrating high yields and good functional group tolerance of the method. Additionally, a gram scale synthesis confirms the scalability of the approach.