Hydrogen-Atom Transfer Catalysis for C-H Alkylation of Benzylic Fluorides

A photoinduced catalytic C(sp3)-H alkylation of benzylicfluorides is developed. The use of zwitterionic 1,2,3-triazolium amidate as ahydrogen-atom transfer catalyst is uniquely effective for promoting thistransformation. The combination of C-H alkylation with subsequentdisplacement of the C-F bond enables 1,1-difunctionalization of benzylicfluorides, providing rapid access to an array of functionalized molecularentities

Automated summary

In this study, a photoinduced catalytic C(sp3)-H alkylation of benzylic fluorides was developed. The use of zwitterionic 1,2,3-triazolium amidate as a hydrogen-atom transfer catalyst proved uniquely effective for promoting this transformation, enabling 1,1-difunctionalization of benzylic fluorides and providing rapid access to a variety of functionalized molecular entities.