A Three-Step Process to Facilitate the Enantioselective Assembly of Cis-Fused Octahydrophenanthrenes with a Quaternary Stereocenter

A three-step process for the enantioselectiveassembly ofcis-fused octahydrophenanthrenes with a quaternarystereocenter is reported. This synthetic strategy relies on aregioselective gamma-alkylation, a one-pot sequence of asymmetrichydrogenation and oxidation, and an intramolecular enolatearylation to facilitate the rapid and enantioselective constructionofcis-fused octahydrophenanthrene scaffolds with an arylated all-carbon quaternary stereocenter concisely and efficiently.

Automated summary

This study reports a concise and efficient synthetic strategy for the rapid assembly of cis-fused octahydrophenanthrene scaffolds, resulting in the construction of compounds with an arylated all-carbon quaternary stereocenter.