Journal
ORGANIC LETTERS
Volume 24, Issue 14, Pages 2596-2600Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.2c00534
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Funding
- National Natural Science Foundation of China [21573032, 21602026]
- Fundamental Research Funds for the Central Universities [DUT20LK42]
- LiaoNing Revitalization Talents Program [XLYC1802030]
- Natural Science Foundation of Liaoning, China [2019JH3/30100001]
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A palladium-catalyzed cycloisomerization of 2-ethynylbiaryls to 9-methylidenefluorenes is described for the first time. This method is operationally simple and scalable, and exhibits high functional group tolerance.
A palladium-catalyzed cycloisomerization of 2-ethynylbiaryls to 9-methylidenefluorenes is described for thefirst time.The cycloisomerization of 2-ethynylbiaryls proceeded smoothly in the presence of weak acid at low temperature to afford 9-methylidenefluorenes in satisfactory to high yields. This new type of cycloisomerization of 2-ethynylbiaryls is operationally simpleand scalable and exhibits high functional-group tolerance. Various synthetically useful functional groups, such as halogen atoms, aswell as formyl, acetyl, methoxycarbonyl, cyano, and nitro groups, remain intact during the cycloisomerization of 2-ethynylbiaryls.
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