Hybrid nanophotonic-microfluidic sensor for highly sensitive liquid and gas analyses

Today, a lab-on-a-chip is one of the most promising ways to create sensor devices for gas and liquid analysis for environmental monitoring, early diagnosis, and treatment effectiveness assessment. On the one hand, this requires a large number of measurements and, on the other hand, involves minimum consumption of the test analytes. Combination of highly sensitive photonic integrated circuits (PICs) with microfluidic channels (MFCs) is necessary to solve this problem. In this work, PICs based on a silicon nitride platform integrated with MFCs for studying liquids and gases were developed. Different concentrations of isopropanol in de-ionized water were used as the analyte. Based on this, the sensitivity (S) and detection limit (DL) of the analyzed solution were evaluated. Entire system calibration was carried out to calculate S and DL, considering experimental and numerical simulation data. This development may be of interest as a promising platform for environmental monitoring and realization of point-of-care strategy for biomedical applications. (C) 2022 Optica Publishing Group

Automated summary

A lab-on-a-chip is a promising approach for creating sensor devices for gas and liquid analysis in environmental monitoring, early diagnosis, and treatment effectiveness assessment. In this study, a system integrating highly sensitive photonic integrated circuits and microfluidic channels was developed for studying liquids and gases. The sensitivity and detection limit of the analyzed solution were evaluated. This development may have significant implications for environmental monitoring and biomedical applications.