Journal
OPHTHALMOLOGY
Volume 129, Issue 9, Pages 986-996Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.ophtha.2022.04.023
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Funding
- UCL Overseas Research Scholarship
- Fight for Sight, London, United Kingdom [1956A]
- Desmond Foundation
- Wellcome Trust [220558/Z/20/Z]
- Alcon
- United Kingdom Research and Innovation Future Leaders Fellowship
- Moorfields Eye Charity (Springboard Award)
- Career Development Fellowship
- National Eye Institute, National Institutes of Health, Bethesda, Maryland [EY015473, EY032559]
- Research to Prevent Blindness, Inc., New York, New York
- The Glaucoma Foundation, New York, New York
- Astra Zeneca
- Boehringer Ingelheim
- Novartis
- Roche Diagnostics
- Association for Research in Vision and Ophthalmology Foundation (David Epstein Award
- UK Research and Innovation Future Leaders Fellowship (Medical Research Council [MR/T040912/1]
- United Kingdom Department of Health
- National Institute for Health Research
- Eye Hospital NHS Foundation Trust
- UCL Institute of Ophthalmology for a Biomedical Research Centre for Ophthalmology
- Moorfields Eye Charity
- NIHR Biomedical Research Centre at Moorfields Eye Hospital NHS Foundation Trust
- UCL Institute of Ophthalmology
- Alcon Research Institute
- International Glaucoma Association (United Kingdom)
- Medical Research Council, United Kingdom [SP2024/0201, MR/N003284/1]
- Cancer Research United Kingdom [G9502233, C864/A8257]
- Wellcome Trust [220558/Z/20/Z] Funding Source: Wellcome Trust
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The study found that serum levels of total cholesterol, high-density lipoprotein cholesterol, and low-density lipoprotein cholesterol are positively associated with intraocular pressure, while triglyceride levels may be negatively associated.
Purpose: Serum lipids are modifiable, routinely collected blood test features associated with cardiovascular health. We examined the association of commonly collected serum lipid measures (total cholesterol [TC], high-density lipoprotein cholesterol [HDL-C], low-density lipoprotein cholesterol [LDL-C], and triglycerides) with intraocular pressure (IOP). Design: Cross-sectional study in the UK Biobank and European Prospective Investigation into Cancer and Nutrition (EPIC)-Norfolk cohorts. Participants: We included 94 323 participants from the UK Biobank (mean age, 57 years) and 6230 participants from the EPIC-Norfolk (mean age, 68 years) cohorts with data on TC, HDL-C, LDL-C, and triglycerides collected between 2006 and 2009. Methods: Multivariate linear regression adjusting for demographic, lifestyle, anthropometric, medical, and ophthalmic covariables was used to examine the associations of serum lipids with corneal-compensated IOP (IOPcc). Main Outcome Measures: Corneal-compensated IOP. Results: Higher levels of TC, HDL-C, and LDL-C were associated independently with higher IOPcc in both cohorts after adjustment for key demographic, medical, and lifestyle factors. For each 1-standard deviation increase in TC, HDL-C, and LDL-C, IOPcc was higher by 0.09 mmHg (95% confidence interval [CI], 0.06-0.11 mmHg; P < 0.001), 0.11 mmHg (95% CI, 0.08-0.13 mmHg; P < 0.001), and 0.07 mmHg (95% CI, 0.05-0.09 mmHg; P < 0.001), respectively, in the UK Biobank cohort. In the EPIC-Norfolk cohort, each 1-standard deviation increase in TC, HDL-C, and LDL-C was associated with a higher IOPcc by 0.19 mmHg (95% CI, 0.07-0.31 mmHg; P = 0.001), 0.14 mmHg (95% CI, 0.03-0.25 mmHg; P = 0.016), and 0.17 mmHg (95% CI, 0.06-0.29 mmHg; P = 0.003). An inverse association between triglyceride levels and IOP in the UK Biobank (-0.05 mmHg; 95% CI, -0.08 to -0.03; P < 0.001) was not replicated in the EPIC-Norfolk cohort (P = 0.30). Conclusions: Our findings suggest that serum TC, HDL-C, and LDL-C are associated positively with IOP in 2 United Kingdom cohorts and that triglyceride levels may be associated negatively. Future research is required to assess whether these associations are causal in nature. (c) 2022 by the American Academy of Ophthalmology. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
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