4.7 Article

Phase II Study of Cabozantinib in Patients With Bone Metastasis

Journal

ONCOLOGIST
Volume 27, Issue 7, Pages 600-606

Publisher

OXFORD UNIV PRESS
DOI: 10.1093/oncolo/oyac083

Keywords

bone metastasis; cabozantinib; sarcoma; skeletal-related events; MET and VEGF inhibition

Categories

Funding

  1. NCI Cancer Center Support Grant [NIH 5 P30 CA06516]
  2. Exelixis

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This study aimed to find a new medical treatment for bone metastasis by testing the safety and efficacy of cabozantinib in patients with bone metastasis arising from non-breast, non-prostate malignant solid tumors. The results showed that cabozantinib demonstrated clinical activity and safety in heavily pretreated patients with bone metastasis and showed activity in patients with metastatic sarcoma.
Bone metastases are often difficult to manage as they can be symptomatic and skeletal-related events (SREs) can contribute to significant morbidity and declines in performance status. We sought to identify a novel medical treatment for bone metastasis by testing the safety and efficacy of cabozantinib in patients with bone metastasis arising from non-breast, non-prostate, malignant solid tumors. Patients were administered cabozantinib as an oral drug starting at 60 mg per day and radiologic measurements were performed at baseline and every 8 weeks. Thirty-seven patients were enrolled. No SREs were observed throughout the study. Twenty patients had disease measurable by Response Evaluation Criteria in Solid Tumors (RECIST) version 1.1. Four of 20 had a partial response by RECIST. An additional 12 patients had some decrease in tumor burden with nine of these having a decrease in tumor burden of at least 10% by RECIST. Six of the patients with at least a minor response had sarcoma. Sixteen patients had biomarkers of bone turnover measured before and after treatment. Most of these patients demonstrated decrease in urine and serum N-telopeptide and serum C-telopeptide. However, these changes in biomarkers of bone turnover did not correlate with radiographic changes measured by RECIST. This study demonstrates clinical activity and safety for cabozantinib in heavily pretreated patients with bone metastasis and shows activity for cabozantinib in patients with metastatic sarcoma. Bone metastases are often difficult to manage. This article reports on the clinical activity and safety of cabozantinib in patients with bone metastasis and reports activity for cabozantinib in patients with metastatic sarcoma and other cancers.

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