4.8 Article

RNA N6-methyladenosine demethylase FTO promotes pancreatic cancer progression by inducing the autocrine activity of PDGFC in an m6A-YTHDF2-dependent manner

Related references

Note: Only part of the references are listed.
Article Biochemistry & Molecular Biology

HIF-1α-induced expression of m6A reader YTHDF1 drives hypoxia-induced autophagy and malignancy of hepatocellular carcinoma by promoting ATG2A and ATG14 translation

Qing Li et al.

Summary: YTHDF1 plays a key role in hepatocellular carcinoma, with its expression level correlated to hypoxia-induced autophagy, tumor growth, and metastasis, serving as an independent prognostic factor. HIF-1 alpha regulates YTHDF1 transcription under hypoxia to promote translation of autophagy-related genes, contributing to autophagy and malignancy in HCC progression.

SIGNAL TRANSDUCTION AND TARGETED THERAPY (2021)

Article Cell Biology

FTO Demethylates Cyclin D1 mRNA and Controls Cell-Cycle Progression

Mayumi Hirayama et al.

CELL REPORTS (2020)

Review Biochemistry & Molecular Biology

The potential role of RNA N6-methyladenosine in Cancer progression

Tianyi Wang et al.

MOLECULAR CANCER (2020)

Review Oncology

Multidisciplinary standards of care and recent progress in pancreatic ductal adenocarcinoma

Aaron J. Grossberg et al.

CA-A CANCER JOURNAL FOR CLINICIANS (2020)

Article Medicine, General & Internal

Pancreatic cancer

Jonathan D Mizrahi et al.

LANCET (2020)

Review Biochemistry & Molecular Biology

Mechanism of RNA modification N6-methyladenosine in human cancer

Zijian Zhou et al.

MOLECULAR CANCER (2020)

Review Biochemistry & Molecular Biology

Where, When, and How: Context-Dependent Functions of RNA Methylation Writers, Readers, and Erasers

Hailing Shi et al.

MOLECULAR CELL (2019)

Article Multidisciplinary Sciences

m6A mRNA demethylase FTO regulates melanoma tumorigenicity and response to anti-PD-1 blockade

Seungwon Yang et al.

NATURE COMMUNICATIONS (2019)

Review Cell Biology

Reading, writing and erasing mRNA methylation

Sara Zaccara et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2019)

Review Oncology

Novel positioning from obesity to cancer: FTO, an m(6)A RNA demethylase, regulates tumour progression

JiaLing Chen et al.

JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY (2019)

Review Biochemistry & Molecular Biology

Functions of N6-methyladenosine and its role in cancer

Liuer He et al.

MOLECULAR CANCER (2019)

Review Cell Biology

Reading, writing and erasing mRNA methylation

Sara Zaccara et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2019)

Article Biochemistry & Molecular Biology

R-2HG Exhibits Anti-tumor Activity by Targeting FTO/m6A/MYC/CEBPA Signaling

Rui Su et al.

Review Endocrinology & Metabolism

Critical Enzymatic Functions of FTO in Obesity and Cancer

Xiaolan Deng et al.

FRONTIERS IN ENDOCRINOLOGY (2018)

Article Oncology

Association between FTO gene polymorphism (rs9939609 T/A) and cancer risk: a meta-analysis

Xiaoyi Huang et al.

EUROPEAN JOURNAL OF CANCER CARE (2017)

Review Cell Biology

Post-transcriptional gene regulation by mRNA modifications

Boxuan Simen Zhao et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2017)

Article Biochemistry & Molecular Biology

Platelet-derived Growth Factor-C (PDGF-C) Induces Anti-apoptotic Effects on Macrophages through Akt and Bad Phosphorylation

Dain Son et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2014)

Article Multidisciplinary Sciences

N6-methyladenosine-dependent regulation of messenger RNA stability

Xiao Wang et al.

NATURE (2014)

Review Genetics & Heredity

Gene expression regulation mediated through reversible m6A RNA methylation

Ye Fu et al.

NATURE REVIEWS GENETICS (2014)

Review Biochemistry & Molecular Biology

Multifarious functions of PDGFs and PDGFRs in tumor growth and metastasis

Yihai Cao

TRENDS IN MOLECULAR MEDICINE (2013)

Article Biochemistry & Molecular Biology

N6-Methyladenosine in nuclear RNA is a major substrate of the obesity-associated FTO

Guifang Jia et al.

NATURE CHEMICAL BIOLOGY (2011)

Article Biochemistry & Molecular Biology

RNA epigenetics?

Chuan He

NATURE CHEMICAL BIOLOGY (2010)

Editorial Material Ophthalmology

Focus on molecules: Platelet-derived growth factor C, PDGF-C

Hetian Lei et al.

EXPERIMENTAL EYE RESEARCH (2008)

Review Cell Biology

Role of platelet-derived growth factors in physiology and medicine

Johanna Andrae et al.

GENES & DEVELOPMENT (2008)

Article Genetics & Heredity

Variation in FTO contributes to childhood obesity and severe adult obesity

Christian Dina et al.

NATURE GENETICS (2007)

Article Medicine, General & Internal

Sorafenib in advanced clear-cell renal-cell carcinoma

Bernard Escudier et al.

NEW ENGLAND JOURNAL OF MEDICINE (2007)

Article Biochemistry & Molecular Biology

Platelet-derived growth factor (PDGF)-C, a PDGF family member with a vascular endothelial growth factor-like structure

LJ Reigstad et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2003)