Journal
ONCOGENE
Volume 41, Issue 17, Pages 2444-2457Publisher
SPRINGERNATURE
DOI: 10.1038/s41388-022-02236-7
Keywords
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Funding
- National Natural Science Foundation of China [31900616, 81673444, 82003795]
- project of improvement of the scientific ability of Anhui Medical University [2020xkjT009]
- Natural Science Foundation of Anhui Province for young scholars [1908085QH379]
- Open Fund of Key Laboratory of Anti-inflammatory and Immune Medicine, Ministry of Education, P.R. China, Anhui Medical University [KFJJ-2021-01]
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This study explores the potential clinical value and molecular mechanisms of miRNA-22 in tumor cell phagocytosis by macrophages and more efficient T cell priming. miR-22 upregulation enhances the phagocytic ability of macrophages, inhibits glioma cell proliferation and migration, and promotes antigen presentation and efficient T cell priming. The study also identifies HDAC6 as a target and NF-kappa B signaling as a pathway associated with miR-22 in tumor-associated macrophages of glioma.
Macrophage-mediated tumor cell phagocytosis and subsequent neoantigen presentation are critical for generating anti-tumor immunity. This study aimed to uncover the potential clinical value and molecular mechanisms of miRNA-22 (miR-22) in tumor cell phagocytosis via macrophages and more efficient T cell priming. We found that miR-22 expression was markedly downregulated in primary macrophages from glioma tissue samples compared to adjacent tissues. miR-22-overexpressing macrophages inhibited glioma cell proliferation and migration, respectively. miR-22 upregulation stimulated the phagocytic ability of macrophages, enhanced tumor cell phagocytosis, antigen presentation, and efficient T cell priming. Additionally, our data revealed that miR-22-overexpressing macrophages inhibited glioma formation in vivo, HDAC6 was a target, and NF-kappa B signaling was a pathway closely associated with miR-22 in tumor-associated macrophages (TAMs) of glioma. Our findings revealed the essential roles of miR-22 in tumor cell phagocytosis by macrophages and more efficient T cell priming, facilitating further research on phagocytic regulation to enhance the response to tumor immunotherapy.
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