Analysis of the Differences in Ocular Surface Damage and Inflammatory Signs between Healthy and Evaporative Dry Eye Participants

Objective Distinguish between EDE severity levels by analysing the MGLA, conjunctival hyperemia and corneal staining. Methods One hundred participants were recruited based on OSDI, TO, TFBUT, TMH, and LLP to be categorised as healthy (Group 1) or EDE (Group 2). Group 2 was divided into Group 2A (mild symptoms), 2B (moderate), and 2C (severe). MGLA, conjunctival hyperemia, and corneal staining were measured. Results Positive correlation between MGLA, conjunctival hyperemia, and corneal staining were found (all r >= 0.221, p <= 0.027). Significant differences were found: MGLA between Group 1 vs. 2C and 2C vs. 2A or 2B; conjunctival hyperemia between Group 1 vs. 2A, 2B or 2C; corneal staining between Group 1 vs. 2B or 2C and 2A vs. 2B or 2C (all p <= 0.049). Conclusion Severe EDE participants have higher MGLA, conjunctival hyperemia, and corneal staining values than healthy, mild, or moderate EDE participants.

Automated summary

By analyzing MGLA, conjunctival hyperemia, and corneal staining, it is possible to distinguish the severity levels of EDE. Participants with severe EDE have higher values of MGLA, conjunctival hyperemia, and corneal staining compared to those with mild or moderate EDE, as well as healthy participants.