Increased sedentary time and decreased physical activity increases lipoprotein associated phospholipase A2 in obese individuals

Background and aims: Lipoprotein-associated Phospholipase A(2) (Lp-PLA(2)) is a protein produced by inflammatory cells in circulation and is associated with cardiovascular disease (CVD) risk. Physical activity (PA) is known to reduce inflammation and risk for CVD. However, Lp-PLA(2) has yet to be examined in relation to PA and sedentary time. The purpose of this study was to determine if PA and sedentary time impacts Lp-PLA(2 )mass. A total of 25 subjects with an average BMI of 30.6 +/- 5.7 were included in the data analysis. Methods and results: Data collected included anthropometric data, Lp-PLA(2 )mass, peak oxygen uptake (VO(2)peak), resting heart rate and blood pressure, obstructive sleep apnea (OSA) risk, and assessment of PA using an accelerometer. Sedentary minutes per day was positively associated with Lp-PLA(2) (r = 0.41, P < 0.05). Light intensity PA was negatively associated (r =-0.51. P = 0.01) with Lp-PLA(2). When subjects were divided into 2-quantiles by Lp-PLA(2), the group with the higher Lp-PLA(2) mass accumulated more sedentary time per day (P < 0.001) and less light intensity PA per day (P = 0.001). OSA risk and Lp-PLA(2) showed no relationship. Sedentary behavior was higher, and light intensity PA was lower in subjects with hiLp-PLA(2 )mass. No difference was seen in moderate-to-vigorous intensity PA or steps per day. Conclusions: This suggests that, total PA habits, including time spent sedentary and lower intensity PA, impacts the levels of Lp-PLA2, an important inflammatory marker and marker of CVD risk. (C) 2022 The Italian Diabetes Society, the Italian Society for the Study of Atherosclerosis, the Italian Society of Human Nutrition and the Department of Clinical Medicine and Surgery, Federico II University. Published by Elsevier B.V. All rights reserved.

Automated summary

This study aimed to investigate the impact of physical activity and sedentary time on the level of Lp-PLA(2) mass. The results showed a positive correlation between sedentary minutes per day and Lp-PLA(2), and a negative correlation between light intensity physical activity and Lp-PLA(2). Subjects with higher Lp-PLA(2) mass had more sedentary time and less light intensity physical activity. The study suggests that overall physical activity habits, including sedentary time and lower intensity physical activity, affect the levels of Lp-PLA2, an important inflammatory marker and marker of cardiovascular disease risk.