4.5 Article

Association between serum 5-methyltetrahydrofolate and homocysteine in Chinese hypertensive participants with different MTHFR C677T polymorphisms: a cross-sectional study

Journal

NUTRITION JOURNAL
Volume 21, Issue 1, Pages -

Publisher

BMC
DOI: 10.1186/s12937-022-00786-w

Keywords

5-methyltetrahydrofolate; Homocysteine; MTHFR C677T

Funding

  1. National Key Research and Development Program of China [2016YFE0205400, 2018ZX09739010, 2018ZX09301034003]
  2. Science and Technology Program of Guangdong, China [2020B121202010]
  3. Science and Technology Planning Project of Guangzhou [201707020010]
  4. Science, Technology and Innovation Committee of Shenzhen, China [GJHS20170314114526143, JSGG20180703155802047]
  5. Economic, Trade and Information Commission of Shenzhen Municipality, China [20170505161556110, 20170505160926390, 201705051617070]
  6. National Natural Science Foundation of China [81730019, 81973133, 81960074, 81500233]
  7. Research Fund Program of Guangdong Provincial Key Laboratory of Renal Failure Research, Clinical Innovation Research Program of Guangzhou Regenerative Medicine and Health Guangdong Laboratory [2018GZR0201003]
  8. Jiangxi Outstanding Person Foundation
  9. Major projects of the Science and Technology Department, Jiangxi, China [20171BAB205008]

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This study revealed the association between serum homocysteine and 5-methyltetrahydrofolate among Chinese hypertensive adults, which was modified by the MTHFR C677T polymorphism.
Background and aims Clarifying the association between 5-methyltetrahydrofolate and homocysteine and the effect pattern of methylene tetrahydrofolate reductase (MTHFR C677T) may contribute to the management of homocysteine and may serve as a significant reference for a randomized controlled trial of 5-methyltetrahydrofolate intervention. This study aimed to reveal the association between these two biochemical indices. Methods Study population was drawn from the baseline data of the China Stroke Primary Prevention Trial (CSPPT), including 2328 hypertensive participants. 5-methyltetrahydrofolate and homocysteine were determined by stable-isotope dilution liquid chromatography-tandem mass spectrometry and automatic clinical analyzers, respectively. MTHFR C677T polymorphisms were detected using TaqMan assay. Multiple linear regression was performed to evaluate the association between serum 5-methyltetrahydrofolate and homocysteine. Results There was a significant inverse association between 5-methyltetrahydrofolate and homocysteine when 5-methyltetrahydrofolate was <= 10 ng/mL, and this association was modified by MTHFR C677T (per 1-ng/mL increment; All: beta = - 0.50, P < 0.001; CC: beta = - 0.14, P = 0.087; CT: beta = - 0.20, P = 0.011; TT: beta = - 1.19, P < 0.001). Moreover, the decline in trend in genotype TT participants was stronger than in genotype CC participants (P for difference < 0.001) and genotype CT participants (P for difference < 0.001), while there was no significant difference between genotype CC and genotype CT participants (P for difference = 0.757). Conclusions Our data showed a non-linear association between serum homocysteine and 5-methyltetrahydrofolate among Chinese hypertensive adults, however, it could be inversely linearly fitted when serum 5-methyltetrahydrofolate was <= 10 ng/mL, and this association was modified by MTHFR C677T.

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