4.6 Review

Structural insights into the assembly and the function of the plant oxidative phosphorylation system

Journal

NEW PHYTOLOGIST
Volume 235, Issue 4, Pages 1315-1329

Publisher

WILEY
DOI: 10.1111/nph.18259

Keywords

high-resolution structures; oxidative phosphorylation system; plant mitochondria; protein complexes; respiration; structure-function; supercomplexes

Categories

Funding

  1. Deutsche Forschungsgemeinschaft [ME4173/3-1, 400681449/GRK2498]
  2. US Department of Energy, Office of Science, Office of Basic Energy Sciences [DE-SC0022293]
  3. U.S. Department of Energy (DOE) [DE-SC0022293] Funding Source: U.S. Department of Energy (DOE)

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This review summarizes recent findings on the structures of plant OXPHOS complexes, highlighting their plant-specific features and discussing their implications for our understanding of plant respiration and its regulation. The authors propose new hypotheses to be tested and suggest re-evaluating older findings. Further biochemical and structural research on the plant OXPHOS system will lead to a deeper understanding of plant respiration, with significant implications for agriculture, the environment, and society.
One of the key functions of mitochondria is the production of ATP to support cellular metabolism and growth. The last step of mitochondrial ATP synthesis is performed by the oxidative phosphorylation (OXPHOS) system, an ensemble of protein complexes embedded in the inner mitochondrial membrane. In the last 25 yr, many structures of OXPHOS complexes and supercomplexes have been resolved in yeast, mammals, and bacteria. However, structures of plant OXPHOS enzymes only became available very recently. In this review, we highlight the plant-specific features revealed by the recent structures and discuss how they advance our understanding of the function and assembly of plant OXPHOS complexes. We also propose new hypotheses to be tested and discuss older findings to be re-evaluated. Further biochemical and structural work on the plant OXPHOS system will lead to a deeper understanding of plant respiration and its regulation, with significant agricultural, environmental, and societal implications.

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