4.8 Letter

Neutralization of the SARS-CoV-2 Deltacron and BA.3 Variants

Journal

NEW ENGLAND JOURNAL OF MEDICINE
Volume 386, Issue 24, Pages 2340-2342

Publisher

MASSACHUSETTS MEDICAL SOC
DOI: 10.1056/NEJMc2205019

Keywords

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Funding

  1. National Cancer Institute of the National Institutes of Health (NIH) [U54CA260582]
  2. NIH [R01 AI150473, R01 HD095881]
  3. Glenn Barber Fel-lowship from the Ohio State University College of Veterinary Medicine [UL1TR002733, KL2TR002734]
  4. Robert J. Anthony Fund for Cardiovascular Research
  5. JB Cardio-vascular Research Fund
  6. National Center for Advancing Trans-lational Sciences

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The study found that the Delta variant has high resistance to immune responses elicited by vaccines or previous infections, while the BA.3 variant does not show broad cross-resistance.
Neutralization of Deltacron and BA.3 SARS-CoV-2 Variants A small study assessed the neutralization of pseudoviruses composed of the recombinant deltacron and omicron BA.3 variants. BA.3 did not show broad cross-resistance, but deltacron was largely resistant to immune response elicited either by three doses of mRNA vaccines or by previous infection.

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