Journal
NEUROSCIENCE LETTERS
Volume 778, Issue -, Pages -Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.neulet.2022.136585
Keywords
Sigma-1 receptors; Ethanol; Adolescent; Taste aversion; Drinking; PRE-084; Female rats
Categories
Funding
- Spanish Ministry of Health (Government Delegation for the National Plan on Drugs) [PNSD 2020-049]
- Programa Operativo de Garantia Juvenil - Junta de Andalucia
- European Social Fund
- AUIP
- [PICT-2018-00597/PICT-2019-00180]
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The study explored the effects of sigma-1 receptors (S1-R) activation on ethanol-induced conditioned taste aversion (CTA) in early adolescence and terminal adolescence/emerging adulthood in female Wistar rats. The results showed that S1-R activation attenuated the learning of ethanol-induced CTA at terminal adolescence but not at early adolescence. Additionally, S1-R activation did not significantly affect binge-like ethanol intake in terminal adolescents.
Ethanol-induced conditioned taste aversion (CTA) is greater in late adolescence or young adulthood than in early adolescence. The role of the sigma receptor system in this age-related difference has not been extensively explored, particularly in female rats. This study assessed the effects of the activation of sigma-1 receptors (S1-R), via the selective S1-R agonist PRE-084, on ethanol-induced CTA at early or at terminal adolescence/emerging adulthood (28 or 56 days-old at the beginning of the procedures, respectively) in female Wistar rats. The modulation of binge-like ethanol intake by PRE-084 was assessed at terminal adolescence. S1-R activation at the acquisition of ethanol-induced CTA attenuated such learning at terminal but not at early adolescence. PRE-084 did not significantly affect ethanol binge drinking in the terminal adolescents. These results highlight the role of S1-R in ethanol-induced CTA and suggest that differential functionality of this transmitter system may underlie age-specific sensitivities to the aversive effects of ethanol.
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