Journal
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
Volume 137, Issue -, Pages -Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.neubiorev.2022.104642
Keywords
Type 2 diabetes; Cognitive dysfunction; Insulin resistance; Therapeutic approaches; Pathophysiological mechanisms
Categories
Funding
- National Natural Science Foundation of China [81771159, 81974160]
- China National Key Research and Development [2020YFC2009002]
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Type 2 diabetes and its associated cognitive dysfunction have significant impacts on personal health and healthcare systems. This review summarizes potential mechanisms underlying cognitive dysfunction and discusses the potential effects of anti-diabetes methods and neuroprotective natural compounds.
Type 2 diabetes (T2D) and its target organ injuries cause distressing impacts on personal health and put an enormous burden on the healthcare system, and increasing attention has been paid to T2D-associated cognitive dysfunction (TDACD). TDACD is characterized by cognitive dysfunction, delayed executive ability, and impeded information-processing speed. Brain imaging data suggest that extensive brain regions are affected in patients with T2D. Based on current findings, a wide spectrum of non-specific neurodegenerative mechanisms that partially overlap with the mechanisms of neurodegenerative diseases is hypothesized to be associated with TDACD. However, it remains unclear whether TDACD is a consequence of T2D or a complication that co-occurs with T2D. Theoretically, anti-diabetes methods are promising neuromodulatory approaches to reduce brain injury in patients with T2D. In this review, we summarize potential mechanisms underlying TDACD and promising neurotropic effects of anti-diabetes methods and some neuroprotective natural compounds. Constructing screening or diagnostic tools and developing targeted treatment and preventive strategies would be expected to reduce the burden of TDACD.
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